Tsuyoshi Shiga    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Visiting Professor
Language	English
Title	Targeted Endomyocardial Biopsy Using Electroanatomical Voltage Mapping for Patients Suspected of Cardiac Sarcoidosis
Conference	The 79th Annual Scientific Meeting of the Japanese Circulation Society
Promoters	Japanese Circulation Society
Conference Type	Nationwide Conferences
Presentation Type	Speech
Lecture Type	General
Publisher and common publisher	◎SERIZAWA Naoki, SHODA Morio, YOSHIDA Ayano, SUZUKI Tsuyoshi, EJIMA Koichiro, SHIGA Tsuyoshi, HAGIWARA Nobuhisa
Date	2015/04/26
Venue (city and name of the country)	Osaka, JAPAN
Summary	Purpose: Diagnosing cardiac sarcoidosis (CS) is sometimes very challenging due to lack of typical signs. Although a histological diagnosis is crucial of diagnosing CS, the sensitivity of endomyocardial biopsy (EMB) is low. We evaluated the diagnostic contribution of electroanatomical voltage mapping (EVM)-guided EMB in patients with CS. Methods: We studied 12 consecutive patients with a noninvasive probable diagnosis of CS according to current criteria (Japanese Diagnostic Standard and Guideline for Sarcoidosis 2006) and without specific histological findings of CS by traditional EMB. All patients underwent EVM-guided EMB. Intracardiac electrogram voltage amplitude and duration time at biopsy sites were measured manually during the procedure. Results: In all 12 patients, RV bipolar voltage mapping was performed with a 3-D electroanatomical mapping system, and the low voltage area ( < 1.5 mV) was identified at outflow tract and interventricular septum of the RV. Histological samples taken from the low voltage area by a standard bioptome with deflectable long sheath showed typical histopathological findings of CS in 5 patients (42%). Positive biopsy sites were lower voltage amplitude and longer duration time than negative biopsy sites (0.63 vs. 2.64 mV, p=0.051 and 142 vs. 81 ms, p=0.013, respectively). No complication occurred throughout the procedure. Conclusion: EVM-guided EMB is helpful in confirming the diagnosis of CS in probable CS patients who remain undiagnosed by traditional EMB.