所属 医学部 医学科（東京女子医科大学病院） 職種 准教授
|発表タイトル||Activation of Effector Memory and Effecter T Cells in Patients with Heart Failure|
|発表者・共同発表者||◎飯田達郎, 佐藤加代子, 鈴木敦, 志賀剛, 萩原誠久|
|学会抄録||第81回日本循環器学会学術集会 プログラム集 234|
|概要||Introduction: Inflammation is deeply involved in heart failure (HF). It is known that high levels of plasma BNP and IL‒6 after optimized treatment for heart failure are independent risk factors for morbidity and mortality. However it is not known the T cell immunology in HF.
Hypothesis: We hypothesized that the patients with HF have the T cell related immunological disorder.
Methods/Results: One hundred patients with HF (Age:64.0±15.3, Men:66.7%, LVEF:42.5±11.2%) were studied, and compared with 63 controls without HF (Cont). Inflammatory T cell cytokine, IL‒6, IFNγ, and IL17, were increased in peripheral blood of HF (P<0.001, P<0.05, and P<0.001, respectively). Next, to investigate the T cell dysfunction in HF, we examine the memory T cell subsets by FACS. In HF, CD45RA‒CCR7‒effecter memory T cells (TEM) and CD45RA+CCR7‒effecter T cells (TEMRA) were increased. To examine the effector function of T cells, we analyzed T cell phenotype. Activated IFNγ+CD4+Th1 cells, IFNγ+CD8+T cells, and perforin+granzyme+ CD8+Cytotoxic T cells(CTL) were increased in HF depending on the NYHA stages. Finally, the inhibitor of Kv1.3, which has the effect of activation for TEM, decreased INFγ+CD4+Th1 cells, INFγ+CD8+T cells, and CD8+CTL (P<0.01, P <0.01, and P<0.01, respectively).
Conclusions: Activated TEM and Teff were elevated in HF patients. Cytotoxic CD4 and CD8 T cells might have an important role for the outcome of HF patients.