MURAGAKI Yoshihiro    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Visiting Professor
Language	English
Title	Regulatory mechanism of acquired resistance against Talaporfin sodium-mediated photodynamic therapy-induced glioblastoma cell death
Conference	17th international photodynamic association World Congress
Conference Type	International society and overseas society
Presentation Type	Poster notice
Lecture Type	General
Publisher and common publisher	◎KOBAYASHI Tatsuya, NITTA Masayuki, MORI Kentaro, MURAGAKI Yoshihiro, KAWAMATA Takakazu, ICHIMURA Koichi , TOMIYAMA Arata
Date	2019/06/29
Venue (city and name of the country)	Boston,U.S.A.
Society abstract	International photodynamic association World Congress 2019 Technical Program 11070-199
Summary	In recent years, talaporfin sodium-mediated photodynamic therapy (NPe6-PDT) against glioblastoma (GBM) has been developed; however molecular mechanism of NPe6-PDT-dependent GBM cell death has not yet been well elucidated. Therefore, we investigated the molecular machinery of GBM cell death induced by NPe6-PDT using human GBM cell lines. As a result, activation of the stress signaling and suppression of the survival signaling were observed during NPe6-PDT-dependent GBM cell death. In addition, we succeeded in establishment of GBM cell lines with acquired NPe6-PDT resistance and currently investigating further about the machinery which regulates NPe6-PDT resistance in these cells.