所属 研究施設 研究施設 職種 教授
|発表タイトル||Seizures in Patients with Newly Diagnosed IntracranialMeningiomas are Associated with Invasive Tumor Growth|
|発表者・共同発表者||◎チエルノフミハイル, 糟谷英俊, 村垣善浩, 伊関洋, 堀智勝, 岡田芳和|
|学会抄録||日本脳神経外科学会 第72回学術総会 プログラム 462|
|概要||3P-P129-08 ポスター：髄膜腫 3
INTRODUCTION. Symptomatic epilepsy is noted in approximately one third of patients
with intracranial meningiomas. The objective of the present retrospective study was
detailed characterization of the possible association between presence of seizures
and macroscopically invasive tumor growth.
METHODS. The analysis was limited to newly diagnosed convexity and parasagittal
tumors (49 cases). There were 37 women and 12 men (mean age 57 years). The largest
diameter of the neoplasm varied from 1 to 8 cm (mean 4 cm). In 9 patients (18%) the
epileptic seizures were marked at least once during the history of the disease. All
neoplasms underwent surgical removal. Invasive growth of the tumor to the pia mater
or brain tissue was macroscopically identified intraoperatively in 25 cases.
RESULTS. Presence of seizures during history of the disease was positively
associated with the size of meningioma (P = 0.0271) and macroscopically invasive
tumor growth (P = 0.0316). It demonstrated 0.32 sensitivity, 0.96 specificity, 0.89
positive predictive value, and 0.58 negative predictive value for invasive growth of
CONCLUSION. Presence of epileptic seizures in patients with convexity and
parasagittal meningiomas may be predictive for invasive tumor growth.