ムラガキ　ヨシヒロ   MURAGAKI Yoshihiro   村垣　善浩    所属   医学部 医学科（東京女子医科大学病院）    職種   客員教授
言語種別	日本語
発表タイトル	Proton MRS characteristics of intracranial meningiomas
会議名	第67回日本脳神経外科学会総会
学会区分	全国規模の学会
発表形式	ポスター掲示
講演区分	一般
発表者・共同発表者	◎Chernov, Mikhail , 糟谷英俊, 小野由子, 加藤宏一, 村垣善浩, 伊関洋, 堀智勝, 高倉公朋
発表年月日	2008/10/02
開催地 （都市, 国名）	岩手県
学会抄録	日本脳神経外科学会総会CD-ROM抄録集 67回,2J-10-P67-03 2008
概要	2008-10-2:ポスター　髄膜腫・神経鞘腫1 OBJECTIVE The objective of the present analysis was evaluation of possible associations between content of choline-containing compounds (Cho) detected by proton magnetic resonance spectroscopy (MRS) with proliferative activity of meningiomas. MATERIALS AND METHODS One hundred patients (78 women and 22 men; mean age, 56 years) with histologically confirmed meningiomas were included in the study. Before surgery all tumors were evaluated with single-voxel long-echo MRS. RESULTS Histopathological investigation revealed 82 WHO grade I meningiomas, 11 – WHO grade II, and 7 – WHO grade III. MIB-1 index varied from 0% to 27.3% (mean, 3.2%), and in 18 cases, it was more, than 5%. Preoperative MRS-detected Cho content in meningiomas estimated relatively to normal brain tissue varied from 0.13 to 13.11 (mean, 2.28), and was significantly greater in cases with MIB-1 rate more, than 5% (3.13 vs. 2.09; P=0.0444). CONCLUSION MRS-detected Cho content seems to be associated with proliferative activity in meningiomas, and may be potentially helpful for non-invasive identification of biologically aggressive neoplasms.