SUZUKI Kazuhito    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Assistant Professor
Language	English
Title	Improvable nutritional status during hospitalization is associated with long-term prognosis in hospitalized patients with heart failure
Conference	第85回日本循環器学会学術集会
Conference Type	Nationwide Conferences
Presentation Type	Speech
Lecture Type	General
Publisher and common publisher	◎Takada Takuma, JUJO Kentaro, Endo Keiko, Yuichiro Minami, Kishihara Makoto, Shirotani Shota, Endo Nana, Watanabe Shonosuke, Abe Takuro, SUZUKI Kazuhito, Hagiwara Nobuhisa
Date	2021/03/26
Venue (city and name of the country)	奈良県(ハイブリット開催)
Summary	Background: CONUT (CONtrolling NUTritional status) score, which is an index calculated from serum albumin, lymphocyte count and total cholesterol, well represents nutritional status in patients with heart failure (HF). Although high CONUT on admission was associated with cardiovascular (CV) events in HF patients, there has been limited evidence about the impact of the change of CONUT during the hospitalization on the long-term prognosis. Methods: This observational study included 1,705 patients who were hospitalized due to HF and discharged alive. They were classified into 4 groups depending on the CONUT score at admission and at discharge with cut-off of 2 point: (1) Persistent High, (2) high at admission and normal at discharge (High-Normal), (3) normal at admission and high at discharge (Normal-High), and (4) Persistent Normal CONUT score groups. The primary endpoint was a composite of CV death and readmission due to HF. Results: During the observation period of median 525 (interquartile range: 295–898) days, the primary endpoint was occurred in 652 patients (38%). Kaplan-Meier analysis showed the highest rate of combined endpoint in patients with Persistent High CONUT score among 4 subgroups (log-rank for trend: p<0.001). After adjusting for covariates, the hazard ratio for a combined outcome was significantly lower in patients in the High-Normal group than those in the Persistent High CONUT group (hazard ratio: 0.62, 95% confidence interval: 0.40–0.97). Conclusions: The change of nutritional status in patients with HF during the hospitalization was associated with CV death or HF readmission after discharge. Improvement of nutritional status may lead better clinical outcomes in patients with HF.