チエルノフ　ミハイル    Department   School of Medicine(Tokyo Women's Medical University Adachi Medical Center), School of Medicine    Position   Assistant Professor
Language	English
Title	Retrospective multicenter study on results of gamma knife surgery for uveal melanoma in Europe
Conference	ISRS2017 Congress
Conference Type	International society and overseas society
Presentation Type	Speech
Lecture Type	General
Publisher and common publisher	◎CHERNOV Mikhail, STOICA Fery , MURGOI ,Gabriela , STEMPURSZKI Rodica , GRETO Daniela , PEKER Selcuk, YILMAZ Meltem, GOLANOV Andrey , KOSTJUCHENKO Vale, GOLUBEVA Olesya , LISCAK Roman , SIMONOVA Gabriela, NOVACEK Ladislav, IVANOV Pavel , ZUBATKINA Irina , SINYAVSKIY Oleg , RADATZ Matthias , MINDERMANN Thomas
Date	2017/05/31
Venue (city and name of the country)	Montreux, Switzerland
Society abstract	2017 ISRS2017 Program 19
Summary	The objective of the present study was retrospective evaluation of results of Gamma Knife surgery (GKS) for uveal melanoma performed in 8 European Gamma Knife centers (Bucharest, Florence, Istanbul, Moscow, Prague, Saint Petersburg, Sheffield, and Zurich), which agreed to participate and provided required information. Study design presumed collection of the various data (62 investigated variables) on individual patients with creation of the integrated database for further statistical analysis. Primary end-points were overall survival, local tumor control, eye retention rate, and morbidity during follow-up. Secondary end-points were tumor response, preservation of visual function on the affected eye, and incidence of metastatic disease after GKS.In total 349 cases were collected. All patients were treated between July 2001 and October 2015. The stage of treated tumors corresponded to I, IIA, IIB, and IIIA in 26%, 43%, 23% and 7% of cases, respectively. Eye fixation was attained with retrobulbar anesthetic blocking in 65% of cases or suturing of rectus muscles in 24% of cases; in 11% of cases no eye fixation was done. Median marginal dose was 30 Gy (range, 25-30 Gy), median maximal dose was 50 Gy (range, 30-80 Gy), median maximal dose to the ipsilateral optic nerve was 8.7 Gy (range, 0.7