所属 医学部 医学科（東医療センター） 職種 助教
|発表タイトル||Proton MRS characteristics of intracranial meningiomas|
|発表者・共同発表者||◎Chernov, Mikhail , 糟谷英俊, 小野由子, 加藤宏一, 村垣善浩, 伊関洋, 堀智勝, 高倉公朋|
|学会抄録||日本脳神経外科学会総会CD-ROM抄録集 67回,2J-10-P67-03 2008|
OBJECTIVE The objective of the present analysis was evaluation of possible
associations between content of choline-containing compounds (Cho) detected by
proton magnetic resonance spectroscopy (MRS) with proliferative activity of
MATERIALS AND METHODS One hundred patients (78 women and 22 men; mean age, 56 years)
with histologically confirmed meningiomas were included in the study. Before surgery
all tumors were evaluated with single-voxel long-echo MRS.
RESULTS Histopathological investigation revealed 82 WHO grade I meningiomas, 11 –
WHO grade II, and 7 – WHO grade III. MIB-1 index varied from 0% to 27.3% (mean,
3.2%), and in 18 cases, it was more, than 5%. Preoperative MRS-detected Cho content
in meningiomas estimated relatively to normal brain tissue varied from 0.13 to 13.11
(mean, 2.28), and was significantly greater in cases with MIB-1 rate more, than 5%
(3.13 vs. 2.09; P=0.0444).
CONCLUSION MRS-detected Cho content seems to be associated with proliferative
activity in meningiomas, and may be potentially helpful for non-invasive
identification of biologically aggressive neoplasms.