チエルノフ ミハイル
  チエルノフ ミハ
   所属   医学部 医学科(東医療センター)
   職種   助教
言語種別 日本語
発表タイトル Proton MRS characteristics of intracranial meningiomas
会議名 第67回日本脳神経外科学会総会
学会区分 全国規模の学会
発表形式 ポスター掲示
講演区分 一般
発表者・共同発表者◎Chernov, Mikhail , 糟谷英俊, 小野由子, 加藤宏一, 村垣善浩, 伊関洋, 堀智勝, 高倉公朋
発表年月日 2008/10/02
開催地
(都市, 国名)
岩手県
学会抄録 日本脳神経外科学会総会CD-ROM抄録集 67回,2J-10-P67-03 2008
概要 2008-10-2:ポスター 髄膜腫・神経鞘腫1
OBJECTIVE The objective of the present analysis was evaluation of possible
associations between content of choline-containing compounds (Cho) detected by
proton magnetic resonance spectroscopy (MRS) with proliferative activity of
meningiomas.
MATERIALS AND METHODS One hundred patients (78 women and 22 men; mean age, 56 years)
with histologically confirmed meningiomas were included in the study. Before surgery
all tumors were evaluated with single-voxel long-echo MRS.
RESULTS Histopathological investigation revealed 82 WHO grade I meningiomas, 11 –
WHO grade II, and 7 – WHO grade III. MIB-1 index varied from 0% to 27.3% (mean,
3.2%), and in 18 cases, it was more, than 5%. Preoperative MRS-detected Cho content
in meningiomas estimated relatively to normal brain tissue varied from 0.13 to 13.11
(mean, 2.28), and was significantly greater in cases with MIB-1 rate more, than 5%
(3.13 vs. 2.09; P=0.0444).
CONCLUSION MRS-detected Cho content seems to be associated with proliferative
activity in meningiomas, and may be potentially helpful for non-invasive
identification of biologically aggressive neoplasms.