所属 医学部 医学科（東京女子医科大学病院） 職種 准教授
|発表タイトル||Detection of Myocardial Inflammation in Sarcoidosis Using Cardiac Magnetic Resonance T2 Mapping|
|会議名||The 83rd Annual Scientific Meeting of the Japanese Circulation Society (JCS2019)|
|主催者||Japanese Circulation Society|
|発表者・共同発表者||◎WATANABE Eri , NAGAO Michinobu, SAKAI Akiko, NAKAO Risako, ANDO Kiyoe, IMAMURA Yasutaka, SUZUKI Atsushi, SHIGA Tsuyoshi, HAGIWARA Nobuhisa|
|概要||*Poster Session (English) 37 CT MRI Myocardium
Background: T1 and T2 mapping on cardiac MRI are new techniques for assessment of quantitative tissue characterization. 18F-FDG PET is useful to evaluate for myocardial inflammation in cardiac sarcoidosis. T2 mapping has been shown to detect activity of myocardial inflammation in other systemic inflammatory diseases. We investigated the activity of myocardial inflammation and fibrosis using T1 and T2 mapping in patients with sarcoidosis. Methods: Cardiac MR was performed for 10 patients with sarcoidosis and 5 controls. Mid-level of left ventricular short-axis image was divided into 4 segments and septal segment was analyzed for T1 and T2 mapping. Native T1 and T2 were measured before administration of contrast. We defined abnormal 18F-FDG uptake on 18F-FDG PET as myocardial inflammation. Native T1 and T2 were compared in patients with and without myocardial inflammation, and in patients with and without late gadolinium enhancement (LGE). Results: There was no significant difference in native T1 and T2 between controls and patients with sarcoidosis (48.7±2.3 vs. 49.0±4.3ms, 1213±107 vs. 1272±37ms). Three patients had abnormal 18F-FDG uptake on 18F-FDG PET. Seven patients had LGE. T2 in patients with myocardial inflammation was significantly higher than in patients without myocardial inflammation (53.1±5.5 vs. 47.2±2.3ms, p=0.04). Native T1 was significantly lower in patients with LGE than in patients without LGE (1253±34 vs. 1309±31ms, p=0.02). Conclusions: T2 mapping may enable detection of myocardial inflammation noninvasively without radiation and contrast administration in patients with sarcoidosis. This technique can be useful to assess the activity of cardiac sarcoidosis and helpful as the guidance of clinical management.