ミヤタ マリコ   Miyata Mariko
  宮田 麻理子
   所属   医学部 医学科
   職種   教授・講座主任
言語種別 英語
発表タイトル Somatotopic refinement via developing synapse elimination in the whisker sensory thalamus of developing mice
会議名 Saitama Univ. Neuroscience Seminar
招聘 招聘
発表形式 口頭
講演区分 特別講演・招待講演など
発表者・共同発表者◎Mariko Miyata
発表年月日 2013/06/25
開催地
(都市, 国名)
Saitama, Japan
概要 Synapse elimination and strengthening are critical steps for the developmental organization of neural circuit. Afferent synapses in the whisker sensory thalamus undergo developmental synapse elimination even after the whisker map called barreloid is established. However, the physiological meaning in the detail is unclear because what fiber is going to survive and what is not, is poorly characterized.Thus,we generate Krox20Cre:td Tomato transgenic mice in which whisker-related afferent(lemniscal) fibers are specifically labeled. Then, we studied the developmental synapse elimination of the lemniscal fibers in the somatosensory thalamus using the mice. Here we show that non-whisker-related lemniscal fibers were preferentially eliminated in the developing whisker sensory thalamus. Such preferential elimination was more prominent on dendrites than on soma of relay neurons, and was partially dependent on tactile sensory experience. Synaptic maturation coincided with this process, indicating selective strengthening of surviving afferent synapses. Our results imply one of the functional significances of the synapse elimination,refinement of somatotopic information in the developing sensory thalamus.