ミヤタ マリコ   Miyata Mariko
  宮田 麻理子
   所属   医学部 医学科
   職種   教授・講座主任
言語種別 英語
発表タイトル Transection of infraorbital nerve induces multiple innervations of lemniscal fibers onto the relay neuron in the somatosensory thalamus.
会議名 The 32nd Annual Meeting of the Japan Neuroscience Society
学会区分 全国規模の学会
発表形式 ポスター掲示
講演区分 一般
発表者・共同発表者◎Takeuchi Y, Imoto K, Miyata M
発表年月日 2009/09/17
開催地
(都市, 国名)
Nagoya, Japan
学会抄録 Neuroscience Research 65(Suppl. 1),S145 2009
概要 Lesion of peripheral sensory nerve induces reorganization of receptive field in the somatosensory thalamus (VPm). However, it is still unknown functional changes of the individual lemniscal synapse, which convey primary somatosensory inputs to VPm, underlie this phenomenon. Our electrophysiological study has previously demonstrated that the thalamic relay neuron becomes to receive a single lemniscal fiber by postnatal days 21 (P21) after developmental synapse elimination in the rodent VPm. Here, we show that the transection of infraorbital nerve at P21 altered the wiring of this synapse. After 1 week from the surgery, multiple steps of lemniscal EPSCs were observed, implying the additional recruitment of lemniscal fibers. Multiply innervated relay neurons occasionally contained silent synapses which were absent in normal young adult mice. These results indicate the lesion-induced rewiring of lemniscal fibers in the VPm.