ヤマグチ ジユンイチ   YAMAGUCHI JUNICHI
  山口 淳一
   所属   医学部 医学科(東京女子医科大学病院)
   職種   特任教授
言語種別 英語
発表タイトル Impact of Renal Transplantation on Clinical Outcomes After Percutaneous Coronary Intervention
会議名 ACC.19 (68th Annual Scientific Session & Expo)
主催者 American College of Cardiology
学会区分 全国規模の学会
発表形式 ポスター掲示
講演区分 一般
発表者・共同発表者◎SATOMI Natsuko, NAKAO Masashi, EBIHARA Suguru, TANAKA Kazuki, OOTSUKI Hisao, YAMAGUCHI Junichi, HAGIWARA Nobuhisa
発表年月日 2019/03/16
開催地
(都市, 国名)
New Orleans, USA
学会抄録 Journal of the American College of Cardiology 73(9),1146 2019
概要 Background: Renal transplantation (RTx) is one of the great options for hemodialysis (HD) patients to improve their life expectancy, however, little is known about outcomes of renal transplantation patients who underwent percutaneous coronary intervention (PCI). The purpose of the present study was to elucidate the impact of RTx on clinical outcomes after PCI.

Methods: Consecutive 50 RTx patients undergoing PCI from 2002 to 2017 were enrolled. To evaluate the effectiveness of RTx, we retrospectively reviewed HD patients who underwent PCI at the same period. Propensity score matching was performed using logistic regression to control for differences in baseline characteristics. The primary outcome was the incidence of major adverse cardiac event (MACE: a composite of all cause death, non-fatal myocardial infarction [MI] and target vessel revascularization [TVR]).

Results: After propensity matching, 100 patients were classified into the RTx (n=50) and HD (n=50) groups. Median follow up period: 53.5 months (interquartile range, 23.8-79.3). Kaplan-Meier analysis revealed that the incidence of MACE in RTx group was significantly lower than in HD group (P< 0.0001). Moreover, RTx group was associated with lower risk for all cause death (odds ratio [OR]: 0.23; 95% confidence interval [CI]: 0.05 to 0.72; p = 0.01) and TVR (OR: 0.12; 95% CI: 0.04 to 0.29; p < 0.0001).

Conclusion: Our present results suggest that RTx may improve not only life expectancy but also TVR after PCI.