ヤマグチ　ジユンイチ   YAMAGUCHI JUNICHI   山口　淳一    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
言語種別	日本語
発表タイトル	ロータブレーターを使用した高度石灰化病変に対する PCI の長期予後における性差の検討　J2T-ROTA 多施設研究から
会議名	第27回日本心血管インターベンション治療学会学術集会 (CVIT2018)
主催者	日本心血管インターベンション治療学会
学会区分	全国規模の学会
発表形式	口頭
講演区分	一般
発表者・共同発表者	◎大槻尚男, 重城健太郎, 田中一樹, 岡井巌, 土肥智貴, 岡崎真也, 川嶋秀幸, 中島真, 奈良有悟, 興野寛幸, 嵐弘之, 山口淳一, 宮内克己, 代田浩之, 上妻謙, 萩原誠久
発表年月日	2018/08/02
開催地 （都市, 国名）	兵庫県神戸市
概要	Background: The gender difference in long-term clinical prognosis after percutaneous coronary intervention (PCI) with rotational atherectomy (RA) against severe calcified coronary artery is totally unclear in the drug-eluting stent (DES) era.Methods: This is the subanalysis of J2T-ROTA registry that included 1,090 patients undergoing PCI with RA at three hospitals between 2004 and 2014. After the exclusion of patients receiving regular hemodialysis, 788 patients including 570 males and 218 females were finally analyzed. The primary endpoint was major adverse cardiovascular event (MACE) including any death, acute coronary syndrome (ACS) and stroke. Results: Female patients were significantly older, and frequently had chronic kidney disease, presentation of ACS, atrial fibrillation (AF), lower body mass index, poorer lipid profiles and higher levels of C-reactive protein and brain natriuretic peptide than male. Kaplan-Meier analysis showed a significantly higher MACE rate in female (Log-rank: p=0.019) during 1,492 days of median observational period. Multivariate Cox regression analysis revealed that age, comorbidity of AF and values of left ventricular ejection fraction were independent predictors for MACE (HR: 1.07 [95%CI: 1.03-1.11]; HR: 1.91 [95%CI: 1.05-3.50]; HR: 0.95 [95%CI: 0.93-0.97], respectively). However, female gender was not independently associated with MACE.