ヤマグチ ジユンイチ   YAMAGUCHI JUNICHI
  山口 淳一
   所属   医学部 医学科(東京女子医科大学病院)
   職種   特任教授
言語種別 日本語
発表タイトル C-reactive Protein to Prealbumin Ratio on Admission and Mortality in Patients Hospitalized for Acute Heart Failure
会議名 第83回日本循環器学会学術集会
主催者 日本循環器学会
学会区分 全国規模の学会
発表形式 ポスター掲示
講演区分 一般
発表者・共同発表者◎春木伸太郎, 南雄一郎, 沼田まどか, 石田一世, 溝渕景子, 重城健太郎, 山口淳一, 志賀剛, 萩原誠久
発表年月日 2019/03/31
開催地
(都市, 国名)
横浜市
概要 *Poster Session (Japanese)115 Heart Failure (Laboratory/Biomarkers)
Background:Inflammation and malnutrition is a common problem in hospitalized patients with acute heart failure (AHF), and is associated with adverse outcomes. C-reactive protein (CRP) is an acute-phase reactant and a nonspecific marker of systemic inflammation. Recently, growing interest has been placed on prealbumin for nutritional assessment. In addition, prealbumin is a negative acute-phase protein in that its synthesis is suppressed in inflammatory settings in which cytokines stimulate hepatic production of acutephase proteins such as CRP. Therefore, the ratio of CRPto-prealbumin (CP ratio) may be a comprehensive marker of inflammation and malnutrition. Although the CP ratio has been shown to predict mortality in critically ill patients, prognostic impact of CP ratio in AHF patients remains unclear. We thus evaluated the relation of CP ratio with allcause mortality in AHF patients. Methods: We analyzed 257 hospitalized AHF patients who examined CRP and prealbumin levels on admission. Results: Shown in the Figure. Conclusion: The ratio of 2 hepatic proteins, CRP and prealbumin, may be useful in the risk stratification of AHF patients.