|
TSUZUKI Shunsuke
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Assistant Professor |
|
| Language | Japanese |
| Title | Verification of APT image and relationship with T2/FLAIR mismatch sign in WHO2016 brain tumor pathology classification |
| Conference | The 39th Annual Meeting of the Japan Society for Neuro-Oncolog |
| Conference Type | Nationwide Conferences |
| Presentation Type | Poster notice |
| Lecture Type | General |
| Date | 2021/12/05 |
| Holding period | 2021/12/05～2021/12/07 |
| Society abstract | 第39回日本脳腫瘍学会学術集会 プログラム・講演抄録集 147 |
| Summary | Introduction: Amide Proton Transfer Imaging(APT)is an MRI imaging method that images the increased concentration of amide groups in tumors and is expected to be clinically applied to the diagnostic imaging of gliomas.On the other hand,T2/FLAIR mismatch sign(T2/FLms)
has been proposed as an MRI finding specific to astrocytoma with IDH gene mutation.This time,in the WHO2016 Brain Tumor Pathological Classification,we report the verification of the pathological gene classification of APT and the retrospective verification based on the pathological diagnosis results of whether there is a relationship between APT and T2/FLms. Method: We examined 88 cases of preoperative glioma (Grade:G2/3/4)in which APT/T2/FLAIR was imaged.resultIt showed a high value in high malignancy and a significant difference was observed. In the verification of genetic classification, the measured APT values were 1.91 ±0.71 for oligodendroglioma(16 cases),2.58±0.17 for astrocytoma(2 cases),2.40±0.90 for anaplastic oligodendroglioma(12 cases),Anaplastic astrocytoma(20 cases)2.63±0.42,The oligodendroglioma system showed lower values than the astrocytoma system.For anaplastic astrocytoma IDH mutant and glioblastoma IDH mutant,APT measurement values were measured after evaluating the presence or absence of T2/FL ms. (continue) Key words: APT | T2/FLAIR mismatch sign, glioma Keyword: APT, T2/FLAIR mismatch sign, glioma |