Suzuki Atsushi
   Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Assistant Professor
Language English
Title Detection of Myocardial Inflammation in Sarcoidosis Using Cardiac Magnetic Resonance T2 Mapping
Conference The 83rd Annual Scientific Meeting of the Japanese Circulation Society (JCS2019)
Promoters Japanese Circulation Society
Conference Type Nationwide Conferences
Presentation Type Speech
Lecture Type General
Publisher and common publisher◎WATANABE Eri , NAGAO Michinobu, SAKAI Akiko, NAKAO Risako, ANDO Kiyoe, IMAMURA Yasutaka, SUZUKI Atsushi, SHIGA Tsuyoshi, HAGIWARA Nobuhisa
Date 2019/03/30
(city and name of the country)
Yokohama, JAPAN
Summary *Poster Session (English) 37 CT MRI Myocardium
Background: T1 and T2 mapping on cardiac MRI are new techniques for assessment of quantitative tissue characterization. 18F-FDG PET is useful to evaluate for myocardial inflammation in cardiac sarcoidosis. T2 mapping has been shown to detect activity of myocardial inflammation in other systemic inflammatory diseases. We investigated the activity of myocardial inflammation and fibrosis using T1 and T2 mapping in patients with sarcoidosis. Methods: Cardiac MR was performed for 10 patients with sarcoidosis and 5 controls. Mid-level of left ventricular short-axis image was divided into 4 segments and septal segment was analyzed for T1 and T2 mapping. Native T1 and T2 were measured before administration of contrast. We defined abnormal 18F-FDG uptake on 18F-FDG PET as myocardial inflammation. Native T1 and T2 were compared in patients with and without myocardial inflammation, and in patients with and without late gadolinium enhancement (LGE). Results: There was no significant difference in native T1 and T2 between controls and patients with sarcoidosis (48.7±2.3 vs. 49.0±4.3ms, 1213±107 vs. 1272±37ms). Three patients had abnormal 18F-FDG uptake on 18F-FDG PET. Seven patients had LGE. T2 in patients with myocardial inflammation was significantly higher than in patients without myocardial inflammation (53.1±5.5 vs. 47.2±2.3ms, p=0.04). Native T1 was significantly lower in patients with LGE than in patients without LGE (1253±34 vs. 1309±31ms, p=0.02). Conclusions: T2 mapping may enable detection of myocardial inflammation noninvasively without radiation and contrast administration in patients with sarcoidosis. This technique can be useful to assess the activity of cardiac sarcoidosis and helpful as the guidance of clinical management.