志賀 智子
   Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Assistant Professor
Language English
Title Diseases Affecting Thalidomide Embryopathy at around 50 years of Age.
Conference The Teratology Society. 55th Annual Meeting
Conference Type International society and overseas society
Presentation Type Poster notice
Lecture Type General
Publisher and common publisher◎Shiga Tomoko, Shimbo Takuro, Yoshizawa Atsuto, Hinoshita Fumihiko.
Date 2015/06/29
Venue
(city and name of the country)
Montréal, Canada
Society abstract Birth Defects Research Part A: Clinical and Molecular Teratology 103(5),414 2015
Summary Introduction: In utero exposure to thalidomide causes a wide range of birth defects, including phocomelia, hearing loss and visceral disorders, known as thalidomide embryopathy. Fifty years after the first report of thalidomide embryopathy, we conducted the first cross-sectional multicentre study to investigate the development of lifestyle-related diseases and identify risk factors for visceral disorders in subjects with thalidomide embryopathy.
Methods: Seventy-six cases with thalidomide embryopathy (31 men, 45 women) underwent medical examinations between 2011 and 2014 to determine the types of thalidomide embryopathy -related anomalies. (limbs, auditory organs or visceral organs) and lifestyle-related diseases present. Osteoporosis was also evaluated in this study. Logistic multiple regression analyses, adjusted for gender and age, were conducted between thalidomide embryopathy and lifestyle-related diseases and to evaluate association between block vertebra and gallbladder aplasia. This study was funded by a Grant-in-Aid for Research on Regulatory Science of Pharmaceuticals and Medical Devices (grant no.: H23-Iyaku-Shitei-023) from the Ministry of Health, Labour and Welfare of Japan, and in part by Grants-in-Aid for Research from the National Center for Global Health and Medicine (grant no.: 26A-201).
Results: Fatty liver, non-alcoholic fatty liver disease and dyslipidaemia were detected in 52.6%, 35.0% and 23.7% of subjects, respectively, with higher incidences among men. Dyslipidaemia was detected in 40.0% of subjects with fatty liver and was significantly associated with fatty liver (odds ratio = 8.86, p = 0.008). Osteoporosis was detected in 16.7% of subjects, respectively, with higher incidence among limb deformity. Block vertebrae were detected in 44.4% of subjects with gallbladder aplasia, and this association was significant (odds ratio = 9.96, p = 0.006).
Discussion: Subjects with thalidomide embryopathy have also a risk of for lifestyle-related disease as well as the general Japanese population. Movement limitation caused by limb deformity in childhood might introduce osteoporosis. In addition, cervical spine radiography and magnetic resonance imaging are recommended to assess block vertebrae in subjects with thalidomide embryopathy with gallbladder aplasia who develop shoulder pain.