イシド　ミキコ   SHIMIZU MIKIKO   石戸　美妃子    所属   医学部 医学科（東京女子医科大学病院）    職種   講師
言語種別	日本語
発表タイトル	Ventricular Stiffness in Patients with Single Ventricle after Fontan Procedure
会議名	第80回日本循環器学会学術集会
学会区分	全国規模の学会
発表形式	口頭
講演区分	一般
発表者・共同発表者	◎朝貝省史, 稲井慶, 石戸美妃子, 石井徹子, 篠原徳子, 杉山央, 富松宏文, 朴仁三
発表年月日	2016/03/20
開催地 （都市, 国名）	仙台市
概要	Background:Ventricular stiffness has been reported to be involved in heart failure owing to left ventricular diastolic dysfunction. However, the underlying mechanism and clinical significance of ventricular stiffness in patients with a single ventricle after the Fontan procedure are still unclear.Methods:We retrospectively studied 39 patients (mean age, 25.7 years; mean postoperative duration, 18.2 years) with a single ventricle after undergoing the Fontan procedure between July 2013 and September 2015. We examined the correlation between ventricular stiffness and the clinical profile of the patients. We calculated ventricular stiffness by using the following formula: (ventricular end-diastolic pressure [mm Hg] − ventricular minimum pressure [mm Hg])÷ventricular stroke volume (mL) × BGA (m2).Results:Ventricular stiffness showed a negative correlation with 6-minute walk distance (p = 0.008). Ventricular stiffness showed a positive correlation with plasma renin activity (p = 0.02) and central venous pressure (p = 0.046), and was significantly worse in the patients with the right ventricle (p = 0.02) and more moderate atrioventricular valve regurgitation (p = 0.009). In the multivariate analysis, ventricular stiffness was significantly worse in the patients with more moderate atrioventricular valve regurgitation (p = 0.03).Conclusions:In patients with a single ventricle after the Fontan procedure, ventricular stiffness was likely to be related to renin activation and atrioventricular valve regurgitation, which has a negative effect on exercise capacity.