所属 医学部 医学科（東京女子医科大学病院） 職種 助教
|発表タイトル||Predictors for Thrombotic and Bleeding Events in Patients with Atrial Fibrillation Undergoing Percutaneous Coronary Intervention: From TWMU-AF PCI Registry|
|発表者・共同発表者||◎吉川将史, 大槻尚男, 海老原卓, 田中一樹, 中尾優, 重城健太郎, 太田吉実, 齊藤克己, 高木厚, 田中博之, 藤井真也, 本田淳, 森文章, 山口淳一, 萩原誠久|
|概要||*一般演題口述（日本語）1 (CAD) Thromboembolism 1
Background: Regardless of diverse risk-stratification methods proposed, baseline specific risk-scores for adverse events in patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI) have not been established. Methods and Results: Consecutive 816 AF patients in TWMU-AF PCI registry who underwent PCI at 8 hospitals between 2011- 2016 were retrospectively analyzed. We evaluated the prognostic values of baseline parameters separately for thrombotic (i.e. myocardial infarction, stent thrombosis and ischemic stroke) and bleeding (TIMI major and minor bleeding) events. On Tables, multivariate Cox regression analysis revealed that insulin-requiring diabetes (HR: 2.93), chronic kidney disease (HR: 2.19) and Multi-vessel disease (HR: 1.97) were independent predictors for thrombotic events. In contrast, Prior stroke (HR 1.67), non-use of proton-pump inhibitor (HR: 1.72) and Triple anti-thrombotic therapy (HR: 1.82) were those for bleeding events. Cumulative risk-score system resulted in significantly lower event rates in patients with lower risk-score, regarding both with thrombotic and bleeding events (both p<0.001, Figures).Conclusion: Simple baseline parameters may predict thrombotic and bleeding events separately in patients with AF undergoing PCI.