SHIMADA ERIKO    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Assistant Professor
Language	English
Title	Clinical Implication of Serum TGF-b Levels in Patients with Fontan Physiology
Conference	The 79th Annual Scientific Meeting of the Japanese Circulation Society
Promoters	Japanese Circulation Society
Conference Type	Nationwide Conferences
Presentation Type	Poster notice
Lecture Type	General
Publisher and common publisher	◎INAI Kei, TSUDA Takeshi, SHIMADA Eriko, NAKANISHI Toshio
Date	2015/04/25
Venue (city and name of the country)	Osaka, JAPAN
Society abstract	PROGRAM JCS 2015 441
Summary	Background and Aim: Transforming growth factor (TGF)-b is a growth factor that has a pivotal role in the regulation of cell growth and inflammation. TGF-b is also known as a downstream growth factor of angiotensin II. The aim of this study is to investigate whether the Fontan operation enhances RAA axis that induces upregulation of systemic TGF-b a possible cause of multiple complications after the Fontan operation. Subjects and Methods: We measured active and total TGF-b levels in the serum by a bioassay using mink lung epithelial cells. Twenty three patients after the Fontan operation and 10 age-matched normal control subjects were recruited. We examined the correlation between serum TGF-b levels and the clinical profiles and sought to elucidate whether there is an association between serum TGF-b levels and the complications related to the Fontan operation. Results: Total and active TGF-b levels in Fontan patients are higher than those in controls, 1.8+/-0.9 vs 0.7+/-0.2 ng/ml, 155.6+/-38.7 vs 59.8+/-16.7 ng/ml, respectively. Active TGF-b levels demonstrated a negative correlation with the cardiac index(p = 0.011), serum creatinine(p = 0.025), and estimated glomerular filtration rate(p = 0.03). Cirrhosis discriminant scores, which indicate the severity of liver fibrosis, were significantly associated with total TGF-b levels. Conclusions: The serum TGF-b levels are associated with the cardiac output and renal /liver dysfunction in Fontan patients.