所属 医学部 医学科（東京女子医科大学病院） 職種 特任助教
|発表タイトル||Impact of Renal Transplantation on Clinical Outcomes After Percutaneous Coronary Intervention|
|会議名||ACC.19 (68th Annual Scientific Session & Expo)|
|主催者||American College of Cardiology|
|発表者・共同発表者||◎SATOMI Natsuko, NAKAO Masashi, EBIHARA Suguru, TANAKA Kazuki, OOTSUKI Hisao, YAMAGUCHI Junichi, HAGIWARA Nobuhisa|
|New Orleans, USA|
|学会抄録||Journal of the American College of Cardiology 73(9),1146 2019|
|概要||Background: Renal transplantation (RTx) is one of the great options for hemodialysis (HD) patients to improve their life expectancy, however, little is known about outcomes of renal transplantation patients who underwent percutaneous coronary intervention (PCI). The purpose of the present study was to elucidate the impact of RTx on clinical outcomes after PCI.
Methods: Consecutive 50 RTx patients undergoing PCI from 2002 to 2017 were enrolled. To evaluate the effectiveness of RTx, we retrospectively reviewed HD patients who underwent PCI at the same period. Propensity score matching was performed using logistic regression to control for differences in baseline characteristics. The primary outcome was the incidence of major adverse cardiac event (MACE: a composite of all cause death, non-fatal myocardial infarction [MI] and target vessel revascularization [TVR]).
Results: After propensity matching, 100 patients were classified into the RTx (n=50) and HD (n=50) groups. Median follow up period: 53.5 months (interquartile range, 23.8-79.3). Kaplan-Meier analysis revealed that the incidence of MACE in RTx group was significantly lower than in HD group (P< 0.0001). Moreover, RTx group was associated with lower risk for all cause death (odds ratio [OR]: 0.23; 95% confidence interval [CI]: 0.05 to 0.72; p = 0.01) and TVR (OR: 0.12; 95% CI: 0.04 to 0.29; p < 0.0001).
Conclusion: Our present results suggest that RTx may improve not only life expectancy but also TVR after PCI.