所属 医学部 医学科（東京女子医科大学病院） 職種 助教
|発表タイトル||Aortic Root Dilatation is Negatively Associated with Left Ventricular Function in Patients with Post-Operative Ventricular Septal Defect|
|発表者・共同発表者||◎福島敬子, 福島教照, 齋藤千紘, 芦原京美, 横田仁子, 内田啓子, 萩原誠久|
|概要||*Poster Session (Japanese) 55 Congenital Heart Disease
Background: Aortic root dilatation (ARD) is frequently found in patients with unrepaired or repaired congenital heart disease. Recently, ARD was reported to observe in also postoperative VSD patients. Furthermore, ARD is associated with an increased risk of heart failure. In this study, we investigated whether ARD was associated with the left ventricular (LV) function in patients with postoperative VSD.Methods: This single-center retrospective survey includes 135 patients aged ≥15 years with surgical repaired VSD who underwent echocardiography between 2009 and 2013. ARD was defined as an observed aortic root diameter/body surface area >2.1 cm/m2. The association between presence of ARD and each echocardiographic measurement were assessed by linear regression adjusted with the propensity score estimating the probability of having ARD for each patient.Results: Forty-four patients (32.6%) had ARD. In the unadjusted analysis, right ventricular systolic pressure, Tei index, and E/e´ were significantly (p<.05) higher in patients with ARD than in those without ARD (31.3±7.5 versus [vs.] 35.4±13.7 mmHg; 0.32±0.10 vs. 0.44±0.15; and 7.1±1.7 vs. 9.5±2.9, respectively). In the propensity score adjusted analysis, significant differences in the Tei index and E/e´ were confirmed between the groups, whereas other echocardiographic measurements were not significantly different.Conclusions: The presence of ARD in patients with postoperative VSD is significantly associated with LV function. The monitoring of aortic root might be important to assess the LV function for patients with postoperative VSD.