KIKUCHI Noriko    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Assistant Professor
Language	English
Title	Prognostic Significance of Myocardial Fibrosis Detected by Magnetic Resonance Imaging in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
Conference	The 79th Annual Scientific Meeting of the Japanese Circulation Society
Promoters	Japanese Circulation Society
Conference Type	Nationwide Conferences
Presentation Type	Speech
Lecture Type	General
Publisher and common publisher	◎TOBITA Takashige, FUKUSHIMA Kenji, SERIZAWA Naoki, KIKUCHI Noriko, YUMINO Dai, SUZUKI Tsuyoshi, SHIGA Tsuyoshi, KIMURA Fumiko, HAGIWARA Nobuhisa
Date	2015/04/26
Venue (city and name of the country)	Osaka, JAPAN
Society abstract	PROGRAM JCS 2015 738
Summary	Background: Late gadolinium enhancement (LGE) in cardiovascular magnetic resonance imaging (CMR) has emerged as an in vivo marker of myocardial fibrosis. The purpose of our study was to evaluate the prognostic significance of LGE in patients with arrhythmogenic right ventricular dysplasia/ cardiomyopathy (ARVD/C) for long-term follow-up.Methods: CMR was performed in the consecutive patients with definite diagnosis of ARVD/C based on the Task Force criteria. The patients were divided into the groups with or without LGE and were followed for 5.4 ±3.2 years (0.1 to 11.5 years). Their right ventricular function was also analyzed. Cardiac death and the unplanned admission for heart failure were defined as the primary end point for cardiac events.Results: LGE was found in 22 out of 36 ARVD/C patients. Cardiac event has occurred in 10 patients with LGE and in 1 patient without. Kaplan-Meier plot showed a significant difference for cardiac events between the groups with LGE and without (p=0.01). Cox proportional-hazards model also showed a statistically significant increased risk of the cardiac event associated with LGE after adjusting for right ventricular dysfunction (<30%) as a confounding factor (hazard ratio: 8.39, 95% confidence interval: 1.45-160.5, P=0.01).Conclusion: Our results suggested that the LGE detected by CMR was predictive of adverse outcome in patients with ARVD/C.