所属 医学部 医学科（東京女子医科大学病院） 職種 助教
|発表タイトル||Baseline nutritional status predicts long-term amputation-free survival in patients undergoing endovascular therapy|
|会議名||ACC.18 (67th Annual Scientific Session & Expo)|
|主催者||American College of Cardiology|
|発表者・共同発表者||◎MIZOBUCHI Keiko, JUJO Kentaro, MINAMI Yuichiro, ISHIDA Issei, HARUKI Shintaro, KADOWAKI Hiromu, TANAKA Kazuki, AKASHI Madoka, KAMETANI Motoko, NAKAO Masashi, YAMAGUCHI Junichi, HAGIWARA Nobuhisa|
|学会抄録||Journal of the American College of Cardiology 71(11),Supplement A1234 2018|
|概要||Background: The CONUT (CONtrolling NUTritional) score is simple index calculated from the following factors; serum albumin concentration, total peripheral lymphocyte count and total cholesterol concentration, and has been reported to well represent nutritional status in hospitalized patients. We aimed to determine prognostic value of CONUT score in patients with peripheral artery disease (PAD).
Methods: This study included 599 consecutive patients who received endovascular therapy (EVT) between 2013 and 2016. Patients were divided into 4 groups based on CONUT score: low risk (score 0: n=73), mild risk (score 1-2: n=265); moderate risk (score 3-4: n=197) and high risk (score >/=5: n=64). The primary endpoint of this study was major amputation-free survival (AFS).
Results: Higher CONUT class included patients with higher rates of chronic kidney disease (CKD) and critical limb ischemia (CLI). During the follow-up period, 64 deaths (11%) and 33 major amputations (6%) were observed. Kaplan-Meier analysis of the 4 subgroups revealed that patients with higher CONUT class had the higher risk for AFS (log-rank: p<0.001, Figure). In univariate Cox regression analysis, higher CONUT class had a significantly higher hazard ratio (HR) of AFS. This finding retained significance even after adjustment for age, gender and morbidity of CKD and CLI (HR: 1.92, 95% confidence interval: 1.47-2.51).
Conclusion: CONUT score may predict long-term adverse clinical events after EVT in PAD patients.