山田　隆弘    Department   School of Medicine(Tokyo Women's Medical University Adachi Medical Center), School of Medicine    Position   Assistant Professor
Language	English
Title	Prognostic Implications of Time between Balloon to Peak Creatinine Kinase-MB in Patients with Acute Myocardial Infarction Undergoing Primary PCI
Conference	The 83rd Annual Scientific Meeting of the Japanese Circulation Society (JCS2019)
Promoters	Japanese Circulation Society
Conference Type	Nationwide Conferences
Presentation Type	Speech
Lecture Type	General
Publisher and common publisher	◎ISHIDA Issei, JUJO Kentaro, HATA Takehiro, KAMISHIMA Kazuho, SHIBAHASHI Eiji, SHIMAZAKI Kensuke, YAMADA Takahiro, SHIOZAKI Natsuko, KATAOKA Shohei, MORIOKA Yuta, OKA Toshiaki, OOTA Yoshimi, SAITO Katsumi, HONDA Atsushi, TANAKA Hiroyuki, HAGIWARA Nobuhisa
Date	2019/03/31
Venue (city and name of the country)	Yokohama, JAPAN
Summary	*Oral Presentation (English)33 ACS/AMI BACKGROUND: Peak creatine kinase-MB (CK-MB) level is associated with clinical outcomes after acute myocardial infarction (AMI). However, the prognostic impact of time between balloon and peak CK-MB (BP-time) after percutaneous coronary intervention (PCI) is unclear. METHODS: This multicentral observational study initially included 1,354 AMI patients undergoing primary PCI within 24 hours after the onset between 2011-2016. After the exclusion of patients with unknown onset time of AMI, patients with the highest CK-MB at baseline, and patients without postPCI TIMI grade 3 flow, 954 patients were ultimately enrolled. They were divided into 4 groups by BP-time with 3-hour increment. The primary endpoint was all-cause mortality. RESULTS: Kaplan-Meier analysis showed that patients with BP-time<3-hours had the lowest, and with BP-time<9-hours had the highest mortality (at 3 years: 5.5% vs. 11.6%, Figure). Multivariate Cox regression analysis revealed that BP-time was an independent predictor of all-cause mortality (HR: 1.06 (95% CI: 1.02-1.11), p=0.003). CONCLUSION: The time between balloon and peak CK-MB was associated with all-cause mortality in the primary PCI with DES era.