TAKADA Takuma    Department   Research Institutes and Facilities, Research Institutes and Facilities    Position   Assistant Professor
Language	English
Title	The Incidence of Occult Cancer after Diagnosis of Venous Thromboembolism in the Current Era: From the COMMAND VTE Registry-2
Conference	第87回日本循環器学会学術集会
Conference Type	Nationwide Conferences
Presentation Type	Speech
Lecture Type	General
Publisher and common publisher	Yugo Yamashita, Ryuki Chatani, Kazuhisa Kaneda, Yuji Nishimoto, Nobutaka Ikeda, Yohei Kobayashi, Satoshi Ikeda, Kite Kim, Toru Takase, Shuhei Tsuji, Maki Ohi, Takuma Takada, Kazunori Otsui, Jiro Sakamoto, Yoshito Ogihara, Ryusuke Nishikawa
Date	2023/03/10
Venue (city and name of the country)	福岡
Summary	Background: Venous thromboembolism (VTE) may be the earliest sign of cancer, although there is no established screening strategies for occult cancer, which could be partly due to lack of the real-world incidence of occult cancer after diagnosis of VTE in the current Era. Methods: The COMMAND VTE Registry-2 is a multicenter registry enrolling 5197 consecutive acute symptomatic VTE patients among 31 centers in Japan between January 2015 and August 2020. The current study population was consisted of 3690 patients without active cancer at diagnosis, who were divided into patients with newly-diagnosed cancer during the follow-up period (N=211, 5.7%) and those without (N=3468, 93.3%). Results: The cumulative incidences of newly-diagnosed cancer were 2.6% at 1-year, 6.0% at 3-year, 10.2% at 5-year, and 15.1% at 7-year. The most common types of newly-diagnosed cancer was colon (19.4%), followed by lung (16.1%) and stomach (8.5%). Although patients with newly-diagnosed cancer were older than those without (71.7 vs. 67.3 years, P<0.001), there were few statistically significant differences in baseline clinical characteristics between the groups including thrombus site and severity of pulmonary embolism. Whereas the cumulative incidences of newly-diagnosed cancer were significantly different depending on presence or absence of transient or persistent provoking factors (Transient risk factor: 4.5%; Unprovoked: 6.0%; Persistent risk factor: 9.5% at 3-year, P=0.002). Conclusions: In the current Era when imaging examinations are widely available, the incidence of newly-diagnosed cancer seemed to be relatively low but not none. Considering the risk difference depending on presence or absence of provoking factors, screening strategies for occult cancer based on individual risks could be useful.