TAKADA Takuma    Department   Research Institutes and Facilities, Research Institutes and Facilities    Position   Assistant Professor
Language	English
Title	Chronic Thromboembolic Pulmonary Hypertension after Acute Pulmonary Embolism in the Era of Direct Oral Anticoagulants: From the COMMAND VTE Registry-2
Conference	第87回日本循環器学会学術集会
Conference Type	Nationwide Conferences
Presentation Type	Speech
Lecture Type	General
Publisher and common publisher	Nobutaka Ikeda, Ryuki Chatani, Kazuhisa Kaneda, Yuji Nishimoto, Yohei Kobayashi, Satoshi Ikeda, Kite Kim, Toru Takase, Shuhei Tsuji, Maki Ohi, Takuma Takada, Kazunori Otsui, Jiro Sakamoto, Yoshito Ogihara, Yugo Yamashita
Date	2023/03/10
Venue (city and name of the country)	福岡
Summary	Background: Chronic thromboembolic pulmonary hypertension (CTEPH) is a life-threatening complication after acute pulmonary embolism (PE). The incidence has not been fully evaluated in the era of direct oral anticoagulants (DOACs). Methods: The COMMAND VTE Registry-2 is a multicenter registry enrolling 5197 consecutive acute symptomatic venous thromboembolism patients among 31 centers in Japan. From the database, the incidence of CTEPH was ascertained. COMMAND-CTEPH Risk Score was created based on the results of Cox regression analysis to stratify the risk of development of CTEPH. Results: After a median 747-days follow-up of 2787 acute-PE patients, 48 CTEPH were identified (cumulative incidence 2.4%). There was no significant difference in the incidence of CTEPH between maintenance treatments of DOACs (2.3%) and warfarin (3.7%). Of the acute-PE patients with a Command-CTEPH Risk Score of 4 (maximum), 35.3% developed CTEPH. Conclusions: The cumulative incidence of CTEPH after acute-PE in the DOACs era was 2.4%. Stratification of risk of developing CTEPH may be useful for follow-up of PE.