タカハシ　リナ   TAKAHASHI Rina   高橋　利奈    所属   医学部 医学科（東京女子医科大学病院）    職種   助教
言語種別	英語
発表タイトル	Glycemic Status in Recruited Participants of the Plant-Focused Nutrition in Diabetic Kidney Disease (PLAFOND) Randomized Controlled Trial
会議名	ASN Kidney Week 2025
学会区分	国際学会及び海外の学会
発表形式	ポスター掲示
発表者・共同発表者	◎Tran Diana, Rhee Connie, Bross Rachelle, Cervantes Mackenzie Kerr, Jerman Nikki, Lopez Pena, Erika, Iloenyosi Arinzechukwu Sean, Landa Janet, Ismail Adnan M., Takahashi Rina, Simon Lewis, Jiang Luohua, Kopple Joel D., Dukkipati Ramanath B., Shah Anuja P., Kalantar-Zadeh Kamyar,
発表年月日	2025/11/07
国名	アメリカ合衆国
開催地 （都市, 国名）	Houston, USA
開催期間	2025/11/05～2025/11/09
学会抄録	American Society of Nephrology 36(10S)
概要	Background: Chronic kidney disease (CKD) and diabetes mellitus frequently co-occur, known as Diabetic Kidney Disease (DKD). Dietary management remains controversial in patients with DKD. While low-protein diets are often recommended in CKD, plant-focused diets may raise concerns over protein-energy wasting and glycemic control, and hypoglycemia may develop with low hemoglobin A1c, known as “burnt-out diabetes”. Methods: We examined glycemic status, using serum glucose and hemoglobin A1c, in the recruited participants of the “Plant Focused Nutrition in DKD” (PLAFOND) randomized controlled trial, with eligibility criteria of documented diagnosis of diabetes and CKD, defined as eGFR <60 ml/min/1.73m2. Results: In the first 74 recruited patients of the PLAFOND trial, the mean age is 58.6 years; 64% are male, 15% Black American, and 74% Hispanic. The mean eGFR is 29.6 ml/min/1.73m2. The mean random serum glucose is 142 mg/dL and A1c is 7.4%. Table 1 shows patient distribution across CKD stages. Figure 1 shows that more than one-third (36%) of patients had A1c <6.5%. While A1c and glucose correlated (R=0.64, p <0.01 in multivariate models), there was no significant correlation between A1c or glucose with eGFR (R<0.07, p>0.2), but mean A1c in CKD Stages 4 and 5 was significantly lower than that in Stage 3 (p<0.05). Conclusion: In the first 74 PLAFOND trial patients, hemoglobin A1c tends to be lower than expected with one-third of the patients exhibiting A1c<6.5%. Whether low protein, plant-dominant diet affects glycemic status and burnt-out diabetes will be investigated in the PLAFOND Study.