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キタハラ シュウジ
KITAHARA Shuji
北原 秀治 所属 医学研究科 医学研究科 (医学部医学科をご参照ください) 職種 特任准教授 |
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| 言語種別 | 英語 |
| 発表タイトル | Prognostic Factors and Talaporfin Sodium Concentration in Photodynamic Therapy for Recurrent Grade 4 Glioma |
| 会議名 | 2025 WFNOS/SNO Annual Meeting, the 30th Society for Neuro-Oncology Annual Meeting & Education Day |
| 学会区分 | 国際学会及び海外の学会 |
| 発表形式 | ポスター掲示 |
| 講演区分 | 一般 |
| 発表者・共同発表者 | ◎ONODERA Mikoto, KITAHARA Shuji, SATO Yasuto, KAWAMATA Takakazu, MURAGAKI Yoshihiro, MASAMUNE Ken |
| 発表年月日 | 2025/11/21 |
| 開催地 （都市, 国名） |
Honolulu, Hawaii. |
| 開催期間 | 2025/11/19～2025/11/23 |
| 学会抄録 | 2025 WFNOS/SNO Annual Meeting web Program 41 |
| 概要 | Background: Although extensive resection improves the prognosis of gliomas, it risks impairing critical brain functions. Photodynamic therapy (PDT) utilizing talaporfin sodium (TS) targets tumor cells upon light activation. Despite its approval in Japan, TS application remains restricted, and factors influencing its efficacy are unclear. We aimed to identify TS efficacy determinants to optimize treatment outcomes.
Methods: Data from 171 patients with grade 4 glioma who underwent surgery and PDT at Tokyo Women’s Medical University Hospital between January 2017 and March 2024 were retrospectively analyzed. Clinical variables evaluated included age, sex, genotype, Karnofsky Perfor- mance Status (KPS), serum albumin (Alb) levels, MIB-1 expression levels, and medication history. TS concentrations in tumor tissues were quantitatively assessed in 82 patients (41 primary, 41 recurrent). Survival outcomes were analyzed. RNA-seq was performed on the three highest and three lowest TS concentration samples with significant TS concentra- tion variations to investigate corresponding gene expression changes. Results: Multivariate analysis identified KPS (hazard ratio [95% confidence interval]: 0.96 [0.93–0.99], p = 0.01) and Alb (3.68 [1.05–13.76], p = 0.047) as independent prognostic factors. In recurrent cases, higher TS concentrations were significantly associated with improved survival (p = 0.0454). RNA-seq analysis indicated decreased expression of ACTB and PDPN genes in samples with lower TS concentrations, suggesting potential resistance mechanisms. Conclusions: TS concentration is a critical determinant of PDT efficacy, especially in recurrent glioma, highlighting its prognostic significance. Alb may affect treatment outcomes by mediating TS binding. RNA-seq findings imply that low TS concentrations may suppress immune and stress response-related genes, potentially diminishing PDT sensitivity. |