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ホシノ ジュンイチ
Hoshino Junichi
星野 純一 所属 医学部 医学科（東京女子医科大学病院） 職種 教授・基幹分野長 |
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| 言語種別 | 日本語 |
| 発表タイトル | Efficacy of Combined Exercise and Nutritional Intervention for Nondialysis-Dependent CKD: A Systematic Review |
| 会議名 | Kidney Week 2025 |
| 主催者 | American Society of Nephrology |
| 学会区分 | 国際学会及び海外の学会 |
| 発表形式 | ポスター掲示 |
| 講演区分 | 一般 |
| 発表者・共同発表者 | ◎Tsuchida Yohei, Kabasawa Hideyuki, Uno Chiharu, Nishioka Shinta, Sofue Tadashi, Fujii Naohiko, Saitoh Masakazu, Narita Ichiei, Yamagata Kunihiro, Hoshino Junichi, Doi Etsuko, Hosojima Michihiro |
| 発表年月日 | 2025/11/07 |
| 国名 | アメリカ合衆国 |
| 開催地 （都市, 国名） |
Houston, USA |
| 開催期間 | 2025/11/05～2025/11/09 |
| 概要 | Background
Various exercise and nutritional interventions have been shown to have beneficial effects in non-dialysis chronic kidney disease (CKD) patients, but their combined efficacy is unclear. This study analyzed the efficacy of combined exercise and nutritional intervention for non-dialysis CKD patients in terms of survival rate, renal function, initiation rate of renal replacement therapy (RRT), muscle mass, physical function including peak volume of oxygen uptake (VO2 peak), and quality of life (QOL). Methods Database searches were performed of PubMed for English-language articles and Ichu-shi web for Japanese-language articles up to 30 September 2024. Inclusion criteria were randomized controlled trials (RCTs) of adult patients with CKD (stages 3–5), excluding patients undergoing RRT and post-kidney transplant, in which the intervention group received combined exercise and nutritional intervention, and the control group received exercise intervention alone, nutritional intervention alone, or no intervention. Cochrane risk-of-bias tool for randomized trials ver. 2 and Cochrane Review Manager were used to assess the risk of bias in RCTs and meta-analyses, respectively. Results Five RCTs involving a total of 339 participants were analyzed. The intervention was associated with a significant improvement in VO2 peak [mean difference = 2.70; 95% confidence interval: 1.22, 4.18], but no difference in renal function was observed in non-dialysis CKD patients compared with the control. The analyzed studies had substantial heterogeneity and risk of bias. The outcomes, including survival rate, initiation rate of RRT, muscle mass, and QOL, were qualitatively summarized due to the small number of studies. Conclusion Combined exercise and nutritional intervention have significant benefits in terms of improving VO2 peak in non-dialysis CKD patients. More RCTs are needed in order to provide evidence-based validation of the efficacy of combined exercise and nutritional intervention for patients with non-dialysis CKD. |