カタオカ　ヒロシ   KATAOKA Hiroshi   片岡　浩史    所属   医学部 医学科（東京女子医科大学病院）    職種   講師
言語種別	英語
発表タイトル	Intracranial Aneurysms and Hemorrhages in ADPKD: An Attribute-Based Cross-Classification Analysis in a Nationwide Japanese Cohort
会議名	Kidney Week 2025
主催者	American Society of Nephrology
学会区分	国際学会及び海外の学会
発表形式	ポスター掲示
講演区分	一般
発表者・共同発表者	◎Kataoka Hiroshi, Shimada Yosuke, Hoshino Junichi, Nishio Saori, Hiromura Keiju, Isaka Yoshitaka, Muto Satoru
発表年月日	2025/11/08
国名	アメリカ合衆国
開催地 （都市, 国名）	Houston, USA
開催期間	2025/11/05～2025/11/09
概要	Background The prevalence and risk factors for intracranial aneurysm (IA) and intracranial hemorrhage (ICH) in patients with autosomal dominant polycystic kidney disease (ADPKD) remain incompletely defined, particularly regarding demographic and clinical attributes. This study aimed to clarify the prevalence of IA and ICH in a large ADPKD cohort from Japan, where universal neuroimaging screening is recommended. Methods We analyzed data from 4,447 Japanese patients with ADPKD registered in a national database between 2015 and 2017. The presence of IA and ICH was assessed, and associations with clinical variables evaluated using logistic regression. We also conducted cross-classification analyses to explore attribute-based prevalence patterns. Results Overall, 693 patients (15.6%) had IA, increasing to 19.2% among those who underwent magnetic resonance angiography. ICH was observed in 256 patients (5.8%). Risk factors significantly associated with IA included female sex (OR=1.52, P<0.001), hypertension (OR=1.46, P=0.002), age ≥50 years (OR=1.39, P<0.001), and CKD stages 4–5 (OR=1.29, P=0.005). For ICH, only hypertension was significant (OR=1.83, P=0.003). An interaction between female sex and age ≥50 was noted for IA (P=0.022), indicating female sex was a risk factor only in older patients. Cross-classification revealed a high IA prevalence in women aged ≥50 (27.7%) and those with CKD stages 4–5 (28.8%). Conclusion This analysis of the world’s largest ADPKD cohort highlights the substantial prevalence of IA and ICH in Japanese patients and underscores the importance of attribute-based risk stratification. These findings support individualized screening, particularly in older women and those with advanced CKD.