サコタ　モモコ   SAKOTA Momoko   迫田　桃子    所属   医学部 医学科（東京女子医科大学病院）    職種   助教
言語種別	英語
発表タイトル	Hypertriglyceridemia and Kidney Prognosis in ADPKD: Insights from Attribute-Based Cross-Classification by Sex and Age
会議名	Kidney Week 2025
主催者	American Society of Nephrology
学会区分	国際学会及び海外の学会
発表形式	ポスター掲示
講演区分	一般
発表者・共同発表者	◎Kataoka Hiroshi, Mochizuki Toshio, Manabe Shun, Ushio Yusuke, Seki Momoko, Tsuchiya Ken, Nitta Kosaku, Hoshino Junichi
発表年月日	2025/11/08
国名	アメリカ合衆国
開催地 （都市, 国名）	Houston, USA
開催期間	2025/11/05～2025/11/09
概要	Background The 2024 KDIGO conference emphasized shifting from a one-size-fits-all model to individualized CKD care. Hypertriglyceridemia may contribute to disease progression in autosomal dominant polycystic kidney disease (ADPKD), but its prognostic impact remains unclear, especially across sex and age groups. This study examined its effect on renal outcomes using an Attribute-Based Medicine (ABM) approach with sex–age cross-classification. Methods We analyzed 553 ADPKD patients not receiving renal replacement therapy (median age: 43 years; eGFR: 55.9 mL/min/1.73 m2; total kidney volume: 1335.4 mL). Hypertriglyceridemia was defined as serum triglycerides ≥150 mg/dL or use of lipid-lowering agents. Patients were cross-classified by sex (men/women) and age (<50/≥50 years). The renal outcome—≥30% eGFR decline or initiation of renal replacement therapy—was assessed via Cox regression. Interaction between hypertriglyceridemia and age ≥50 was evaluated in multivariable models. Mean follow-up was 6.9 years; 266 patients experienced renal events. Results Hypertriglyceridemia was not linked to worse renal prognosis in the overall cohort (HR=1.06, P=0.719). No significant interaction was seen between hypertriglyceridemia and age ≥50 in either sex (interaction P=0.452 men, 0.678 women). Cross-classification showed a significant and clinically relevant association between hypertriglyceridemia and poor outcomes in women <50 years (HR=3.15, P=0.018). No significant associations appeared in other subgroups. These findings suggest hypertriglyceridemia may detrimentally affect renal prognosis in younger women with ADPKD, underscoring the value of attribute-based risk assessment. Conclusion Hypertriglyceridemia may be a modifiable risk factor for renal progression in ADPKD, especially in younger women. Attribute-based cross-classification offers useful insight for personalized risk.