タネダ　セキコ   TANEDA Sekiko   種田　積子    所属   医学部 医学科（東京女子医科大学病院）    職種   准教授
言語種別	英語
発表タイトル	PLA2R-positive membranous nephropathy in IgG4-related disease
会議名	第16回 日本IgG4関連疾患学会学術集会
学会区分	全国規模の学会
招聘	招聘
発表形式	口頭
講演区分	一般
発表者・共同発表者	◎Ushio Yusuke, Akihisa Taro, Karasawa Kazunori, Seki Momoko, Kobayashi Shizuka, Miyabe Yoei, Kataoka Hiroshi, Ito Naoko , Taneda Sekiko , Akiyama Shinichi, Hebisawa Akira, Kawano Mitsuhiro, Honda Kazuho, Hoshino Junichi
発表年月日	2025/03/08
国名	日本
開催地 （都市, 国名）	神戸
開催期間	2025/03/08～2025/03/09
学会抄録	BMC Nephrology 25(1),66
概要	Background IgG4-related disease (IgG4-RD) is a fibroinflammatory disease that affects multiple organs, including the pancreas, lacrimal glands, salivary glands, periaortic/retroperitoneum, and kidney. Interstitial nephritis is a typical renal disorder associated with IgG4-RD, but membranous nephropathy is also seen in some cases. Case presentation Herein we report on the case of a 77-year-old male patient with nephrotic syndrome and IgG4-related lung disease. His serum phospholipase A2 receptor (PLA2R) antibody was positive. His renal biopsy specimen was also positive for PLA2R. The renal biopsy specimen showed membranous nephropathy with equal IgG3 and IgG4 immunofluorescence staining and no interstitial nephritis, suggesting IgG4-RD manifesting as membranous nephropathy. Conclusions Nephrotic syndrome caused by membranous nephropathy is sometimes associated with IgG4-RD. In such cases, even if serum PLA2R antibody is positive, it should be considered that the membranous nephropathy may be secondary to IgG4-RD.