マナベ　シユン   Manabe Shiyun   眞部　俊    所属   医学部 医学科（東京女子医科大学病院）    職種   講師
言語種別	英語
発表タイトル	Decreased risk of dialysis-related amyloidosis in the 2010s: Results from Japanese nationwide surveys in 2010 and 2017
会議名	Kidney Week 2024
主催者	American Society of Nephrology
学会区分	国際学会及び海外の学会
発表形式	ポスター掲示
講演区分	一般
発表者・共同発表者	◎Hoshino Junichi, Ushio Yusuke, Kawaguchi Yuki, Manabe Shun, Kataoka Hiroshi, Yamamoto Suguru, Abe Masanori, Hanafusa Norio,
発表年月日	2024/10/25
国名	アメリカ合衆国
開催地 （都市, 国名）	San Diego, USA
開催期間	2024/10/24～2024/10/27
概要	Background Incidences and risk factors of dialysis-related amyloidosis may be changed with improvement of dialysis technologies. In this study, we aimed to clarify recent incidences of operation of carpal tunnel syndrome (CTS) by using two large-scale data. Methods We used the Japan Renal Data Registries for 2010 and 2017 to compare the crude risk of CTS during the following year, excluding patients with a history of CTS, those who received temporary dialysis or transplantation, and those whose data were incomplete or outliners. The crude risks of new CTS among every 5 years of dialysis vintage up to 35 years or more in the 2010 and 2017 cohorts were analyzed. Results A total of 167,793 patients in the 2010 cohort (female, 37%; mean age, 67.4±12.5 years; and mean dialysis vintage, 7.2±6.5 years) and 164,102 patients in the 2017 cohort (female, 35%; mean age, 69.6±12.4 years; and mean dialysis vintage, 7.6±7.0 years) were analyzed. Of the 2010 patients, 1.31% experienced first-time CTS compared with 1.53% of the 2017 cohort. In the 2017 cohort, the crude risks among dialysis vintage 15-20, 20-25, 25-30, 30-35, and over 35 years were 3.2 (95%CI, 2.9-3.5), 6.5 (5.9-7.2), 10.8 (9.7-11.9), 18.3 (16.3-20.5), and 26.3 (23.2-29.6)%, respectively. Those risks were reduced up to 30% from the same dialysis vintage in the 2010 cohort, though the difference was very small in patients with vintage over 35 years. Conclusion We previously reported the incidence of first-time onset of CTS was significantly reduced from 1998 to 2010, especially for patients with longer dialysis vintage. The incidence of CTS was also reduced from 2010 to 2017 among the same vintage group, though the degree of reduction was smaller than the previous decade and not observed in patients with dialysis vintage over 35 years.