フジタ　キヨウヘイ   Fujita Kiyouhei   藤田　恭平    所属   医学部 医学科    職種   助教
言語種別	英語
発表タイトル	MECHANICAL PROPERTIES OF BIO-HYDROGEL FROM CARDIAC EXTRACELLULAR MATRIX
会議名	International Conference on Materials and Processing ICMP2014
学会区分	国際学会及び海外の学会
発表形式	口頭
講演区分	一般
発表者・共同発表者	◎Fujita Kyohei, Kayano Yosuke, Kosawada Tadashi, Sato Daisuke, Nakamura Takao, Shiraishi Yasuyuki, Umezu Mitsuo, Feng Zhonggang
発表年月日	2014/06/09
開催地 （都市, 国名）	Detroit, USA
学会抄録	Proceedings of the JSME/ASME 2014 International Conference on Materials and Processing ICMP2014 1-5 2014
概要	Methods for differentiating stem cells into cardiomyocytes by growth factors have been routinely used. Recently, the method using hybrid gels composed of native heart matrix and collagen has been reported to induce cardiac differentiation of human embryonic stem cells without supplemental growth factors. However, the influence of mechanical properties of the gel has not been thoroughly investigated since mechanical properties of scaffold is one of the critical factors for differentiation. In this study, we fabricate bio-hydrogel composed of goat cardiac extracellular matrix, and investigated the mechanical properties by means of uniaxial compression test. It showed that cardiac ECM gels from goat hearts possess viscoelastic property. The elastic modulus K1 in Kelvin model is at 6.3~18.6 Pa for these gels and K2 is at 29.6~131.7 Pa, consistently larger than K1. The relaxation coefficient λ is ca. 20 s. Moreover, this study found that the elastic modulus K2 remarkably increased by fixation.