ミナミ　ユウイチロウ   MINAMI Yuuichirou   南　雄一郎    所属   医学部 医学科（東京女子医科大学病院）    職種   准教授
言語種別	英語
発表タイトル	Improvable nutritional status during hospitalization is associated with long-term prognosis in hospitalized patients with heart failure
会議名	第85回日本循環器学会学術集会
学会区分	全国規模の学会
発表形式	口頭
講演区分	一般
発表者・共同発表者	◎Takada Takuma, JUJO Kentaro, Endo Keiko, Yuichiro Minami, Kishihara Makoto, Shirotani Shota, Endo Nana, Watanabe Shonosuke, Abe Takuro, SUZUKI Kazuhito, Hagiwara Nobuhisa
発表年月日	2021/03/26
開催地 （都市, 国名）	奈良県(ハイブリット開催)
概要	Background: CONUT (CONtrolling NUTritional status) score, which is an index calculated from serum albumin, lymphocyte count and total cholesterol, well represents nutritional status in patients with heart failure (HF). Although high CONUT on admission was associated with cardiovascular (CV) events in HF patients, there has been limited evidence about the impact of the change of CONUT during the hospitalization on the long-term prognosis. Methods: This observational study included 1,705 patients who were hospitalized due to HF and discharged alive. They were classified into 4 groups depending on the CONUT score at admission and at discharge with cut-off of 2 point: (1) Persistent High, (2) high at admission and normal at discharge (High-Normal), (3) normal at admission and high at discharge (Normal-High), and (4) Persistent Normal CONUT score groups. The primary endpoint was a composite of CV death and readmission due to HF. Results: During the observation period of median 525 (interquartile range: 295–898) days, the primary endpoint was occurred in 652 patients (38%). Kaplan-Meier analysis showed the highest rate of combined endpoint in patients with Persistent High CONUT score among 4 subgroups (log-rank for trend: p<0.001). After adjusting for covariates, the hazard ratio for a combined outcome was significantly lower in patients in the High-Normal group than those in the Persistent High CONUT group (hazard ratio: 0.62, 95% confidence interval: 0.40–0.97). Conclusions: The change of nutritional status in patients with HF during the hospitalization was associated with CV death or HF readmission after discharge. Improvement of nutritional status may lead better clinical outcomes in patients with HF.