シガ　ツヨシ   Shiga Tsuyoshi   志賀　剛    所属   医学部 医学科（東京女子医科大学病院）    職種   客員教授
言語種別	英語
発表タイトル	Benefit of sinus rhythm restoration in acute decompensated heart failure patients with atrial tachyarrhythmia treated with landiolol
会議名	ESC Congress 2019
主催者	European Society of Cardiology
学会区分	国際学会及び海外の学会
発表形式	抄録のみ
講演区分	一般
発表者・共同発表者	◎SAKAI Masayuki, SUZUKI Atsushi, SHIGA Tsuyoshi, TANAKA Yukako, TOMARI Erina, OSADA Akihiro, MATSUURA Junya, HAYASHI Nauka, MATSUI Yuko, HAGIWARA Nobuhisa
発表年月日	2019/09/02
開催地 （都市, 国名）	Paris, FRANCE
概要	Topic : Heart Failure Sub-topic : Acute Heart Failure: Pharmacotherapy Session type : Abstract Session Background: Atrial tachyarrhythmias (ATA), such as atrial fibrillation / atrial tachycardia are frequently observed in patients with acute decompensated heart failure (ADHF). Because ATA leads to clinical deterioration and worsen HF, the conversion and prevention of ATA is important of ADHF with ATA. Landiolol, an ultrashortacting intravenous beta1 blocker, was developed and has been used for the treatment of ATA. Purpose: We evaluated the acute effect of landiolol treatment on heart rate or blood pressure (BP), also the rates and benefits of sinus rhythm (SR) restoration among AHF patients with ATA treated with landiolol. Methods: We studied 67 consecutive HF patients with ATA (age: 67 +/12 years, 36 male) treated with landiolol from 2015 to December 2017 at our University Hospital. They were compared with 50 paired subjects, matched for gender, age and baseline BP who developed HF with ATA from HIJHF 2 study (consisted of HF patients hospitalized between 2013 and 2014). Results: At the start of landiolol treatment, mean left ventricular ejection fraction (LVEF) was 41±14%. The median maintenance dose of landiolol was 3.0 (1.012.0)μ/kg/min and the median treatment duration of landiolol was 5 (124) days. After 6 hours from administration of landiolol, mean HR decreased significantly from 140±18 to 100±21 bpm (p<0.05), whereas BP was not difference during landiolol treatment. Sinus rhythm was restored spontaneously in 15 (22%), and by electrical or pharmacological cardioversion in 5 (7%) during a treatment with intravenous landiolol. Furthermore, sinus rhythm was restored in 22 patients using additional rhythm control treatment, such as amiodarone or catheter ablation after intravenous landiolol treatement. Eight patients experienced inhospital death. Fortyone (69%) of 59 patients discharged alive were in SR. During the followup period of 16±12 months, 4 patients died and 12 patients experienced rehospitalization due to worsening HF after hospital discharge. There was a significant higher rate of death or HF rehospitalization in patients without SR restoration than patients with SR restoration (44% vs. 20%, p<0.05) (Figure A). Compared with 50 paired subjects from HIJHF 2 study, those who treated with landiolol developed a significant higher rate of SR restoration (68% vs. 20%, p<0.05) (Figure B). Conclusion: This study demonstrated that landiolol treatment was effective for both rate control and conversion to sinus rhythm in ADHF patient with ATA. We should consider that the benefits of rhythm control in ADHF patients with ATA during and after landiolol treatment.