カワマタ　タカカズ   Kawamata Takakazu   川俣　貴一    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
言語種別	英語
発表タイトル	Regulatory mechanism of acquired resistance against Talaporfin sodium-mediated photodynamic therapy-induced glioblastoma cell death
会議名	17th international photodynamic association World Congress
学会区分	国際学会及び海外の学会
発表形式	ポスター掲示
講演区分	一般
発表者・共同発表者	◎KOBAYASHI Tatsuya, NITTA Masayuki, MORI Kentaro, MURAGAKI Yoshihiro, KAWAMATA Takakazu, ICHIMURA Koichi , TOMIYAMA Arata
発表年月日	2019/06/29
開催地 （都市, 国名）	Boston,U.S.A.
学会抄録	International photodynamic association World Congress 2019 Technical Program 11070-199
概要	In recent years, talaporfin sodium-mediated photodynamic therapy (NPe6-PDT) against glioblastoma (GBM) has been developed; however molecular mechanism of NPe6-PDT-dependent GBM cell death has not yet been well elucidated. Therefore, we investigated the molecular machinery of GBM cell death induced by NPe6-PDT using human GBM cell lines. As a result, activation of the stress signaling and suppression of the survival signaling were observed during NPe6-PDT-dependent GBM cell death. In addition, we succeeded in establishment of GBM cell lines with acquired NPe6-PDT resistance and currently investigating further about the machinery which regulates NPe6-PDT resistance in these cells.