コヤナギ　チヒロ   Koyanagi Chihiro   小栁　千紘    所属   医学部 医学科（東京女子医科大学病院）    職種   助教
言語種別	英語
発表タイトル	Prognostic Implications of the Mitral L Wave in Patients with Hypertrophic Cardiomyopathy
会議名	The 83rd Annual Scientific Meeting of the Japanese Circulation Society (JCS2019)
主催者	Japanese Circulation Society
学会区分	全国規模の学会
発表形式	口頭
講演区分	一般
発表者・共同発表者	◎SAITO Chihiro, MINAMI Yuichiro, HARUKI Shintaro, ARAI Kotaro, ASHIHARA Kyomi, HAGIWARA Nobuhisa
発表年月日	2019/03/29
開催地 （都市, 国名）	Yokohama, JAPAN
概要	*Featured Research Session 4 (HF/CM) Heart Failure, Cardiomyopathy (Clinical) Background: In hypertrophic cardiomyopathy (HCM), one of the main pathophysiological features is diastolic dysfunction. Diastolic dysfunction detected by restrictive filling pattern was associated with worse outcomes in patients with HCM. However, atrial fibrillation (AF), which is the most common supraventricular sustained arrhythmia in HCM, makes it difficult to accurately evaluate diastolic function. The prominent mid-diastolic filling wave (mitral L-wave) has been indicated advanced diastolic dysfunction even in patients with AF. However, the association between mitral L-wave and outcome in HCM patients remains unclear. We thus evaluated the prognostic implications of mitral L-wave in HCM patients. Methods: This study included 445 HCM patients. The mitral L-wave was defined as a distinct mid-diastolic flow velocity following the E wave with a peak velocity >20 cm/s. The endpoint of this study was the combination of sudden cardiac death, successful resuscitation after cardiac arrest, appropriate implantable cardioverter-defibrillator shocks, heart failure death, and stroke-related death. Results: Shown in Figure. Conclusions: The presence of mitral L-wave may be associated with adverse outcome in patients with HCM.