ヤマグチ　ジユンイチ   YAMAGUCHI Jiyun'ichi   山口　淳一    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
言語種別	日本語
発表タイトル	Predictors for Thrombotic and Bleeding Events in Patients with Atrial Fibrillation Undergoing Percutaneous Coronary Intervention: From TWMU-AF PCI Registry
会議名	第83回日本循環器学会学術集会
主催者	日本循環器学会
学会区分	全国規模の学会
発表形式	口頭
講演区分	一般
発表者・共同発表者	◎吉川将史, 大槻尚男, 海老原卓, 田中一樹, 中尾優, 重城健太郎, 太田吉実, 齊藤克己, 高木厚, 田中博之, 藤井真也, 本田淳, 森文章, 山口淳一, 萩原誠久
発表年月日	2019/03/29
開催地 （都市, 国名）	横浜市
概要	*一般演題口述（日本語）1 (CAD) Thromboembolism 1 Background: Regardless of diverse risk-stratification methods proposed, baseline specific risk-scores for adverse events in patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI) have not been established. Methods and Results: Consecutive 816 AF patients in TWMU-AF PCI registry who underwent PCI at 8 hospitals between 2011- 2016 were retrospectively analyzed. We evaluated the prognostic values of baseline parameters separately for thrombotic (i.e. myocardial infarction, stent thrombosis and ischemic stroke) and bleeding (TIMI major and minor bleeding) events. On Tables, multivariate Cox regression analysis revealed that insulin-requiring diabetes (HR: 2.93), chronic kidney disease (HR: 2.19) and Multi-vessel disease (HR: 1.97) were independent predictors for thrombotic events. In contrast, Prior stroke (HR 1.67), non-use of proton-pump inhibitor (HR: 1.72) and Triple anti-thrombotic therapy (HR: 1.82) were those for bleeding events. Cumulative risk-score system resulted in significantly lower event rates in patients with lower risk-score, regarding both with thrombotic and bleeding events (both p<0.001, Figures).Conclusion: Simple baseline parameters may predict thrombotic and bleeding events separately in patients with AF undergoing PCI.