シガ　ツヨシ   Shiga Tsuyoshi   志賀　剛    所属   医学部 医学科（東京女子医科大学病院）    職種   客員教授
言語種別	英語
発表タイトル	Prognostic Significance of Myocardial Fibrosis Detected by Magnetic Resonance Imaging in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
会議名	The 79th Annual Scientific Meeting of the Japanese Circulation Society
主催者	Japanese Circulation Society
学会区分	全国規模の学会
発表形式	口頭
講演区分	一般
発表者・共同発表者	◎TOBITA Takashige, FUKUSHIMA Kenji, SERIZAWA Naoki, KIKUCHI Noriko, YUMINO Dai, SUZUKI Tsuyoshi, SHIGA Tsuyoshi, KIMURA Fumiko, HAGIWARA Nobuhisa
発表年月日	2015/04/26
開催地 （都市, 国名）	Osaka, JAPAN
学会抄録	PROGRAM JCS 2015 738
概要	Background: Late gadolinium enhancement (LGE) in cardiovascular magnetic resonance imaging (CMR) has emerged as an in vivo marker of myocardial fibrosis. The purpose of our study was to evaluate the prognostic significance of LGE in patients with arrhythmogenic right ventricular dysplasia/ cardiomyopathy (ARVD/C) for long-term follow-up.Methods: CMR was performed in the consecutive patients with definite diagnosis of ARVD/C based on the Task Force criteria. The patients were divided into the groups with or without LGE and were followed for 5.4 ±3.2 years (0.1 to 11.5 years). Their right ventricular function was also analyzed. Cardiac death and the unplanned admission for heart failure were defined as the primary end point for cardiac events.Results: LGE was found in 22 out of 36 ARVD/C patients. Cardiac event has occurred in 10 patients with LGE and in 1 patient without. Kaplan-Meier plot showed a significant difference for cardiac events between the groups with LGE and without (p=0.01). Cox proportional-hazards model also showed a statistically significant increased risk of the cardiac event associated with LGE after adjusting for right ventricular dysfunction (<30%) as a confounding factor (hazard ratio: 8.39, 95% confidence interval: 1.45-160.5, P=0.01).Conclusion: Our results suggested that the LGE detected by CMR was predictive of adverse outcome in patients with ARVD/C.