コヤナギ　チヒロ   Koyanagi Chihiro   小栁　千紘    所属   医学部 医学科（東京女子医科大学病院）    職種   助教
言語種別	英語
発表タイトル	Predictor of Aortic Root Dilatation in Adolescent and Adult Patients with Surgically Repaired Ventricular Septal Defect
会議名	The 79th Annual Scientific Meeting of the Japanese Circulation Society
主催者	Japanese Circulation Society
学会区分	全国規模の学会
発表形式	口頭
講演区分	一般
発表者・共同発表者	◎SAITO Chihiro, FUKUSHIMA Keiko, FUKUSHIMA Noritoshi, MATSUMURA Goki, HATAKEYAMA Shinya, HAYASHI Keiko, ARAI Kotaro, ASHIHARA Kyomi, HAGIWARA Nobuhisa
発表年月日	2015/04/26
開催地 （都市, 国名）	Osaka, JAPAN
学会抄録	PROGRAM JCS 2015 630
概要	Background: Aortic root dilatation (ARD) in congenital heart disease is a deleterious issue induced to aortic regurgitation (AR), aortic aneurysm, and rupture. We sought to determine the predictors of ARD in patients with repaired ventricular septal defect (VSD). Methods and Results: This cross-sectional study included 157 patients with surgically repaired VSD. Echocardiographic findings were assessed to measure the aortic root in a parasternal long-axis view at the level of the sinus of Valsalva. Absolute diameter ≥38mm of aortic root was defined as ARD. The prevalence of the ARD was 16.6% (n=26). After adjustment for gender, duration of shunt, follow-up period after operation, and the presence of AR in a multivariate logistic model, VSD patients with non-subarterial-type was found to have ARD (odds ratio 7.55, 95% confidence interval 1.65 to 34.50, p = 0.009), compared to those with subarterial-type, commonly observed in Asian. Patients with pre-operative right-, or non-coronary cusp prolapsing (RNCCP) was found to have ARD (odds ratio 20.14, 95% confidence interval 3.10 to 130.63, p =0.002), compared in patients without pre-operative RNCCP. Furthermore, larger defect diameter was found to be a risk factor for ARD (odds ratio 1.18, 95% confidence interval 1.06 to 1.31, p =0.002). Conclusion: Anatomical and morphological features (Non-subarteial-types, the presence of pre-operative RNCCP, and defect size) in VSD were independent predictors for the ARD.