ムラガキ　ヨシヒロ   Muragaki Yoshihiro   村垣　善浩    所属   医学部 医学科（東京女子医科大学病院）    職種   客員教授
言語種別	英語
発表タイトル	Retrospective multicenter study on results of gamma knife surgery for uveal melanoma in Europe
会議名	ISRS2017 Congress
学会区分	国際学会及び海外の学会
発表形式	口頭
講演区分	一般
発表者・共同発表者	◎CHERNOV Mikhail, STOICA Fery , MURGOI ,Gabriela , STEMPURSZKI Rodica , GRETO Daniela , PEKER Selcuk, YILMAZ Meltem, GOLANOV Andrey , KOSTJUCHENKO Vale, GOLUBEVA Olesya , LISCAK Roman , SIMONOVA Gabriela, NOVACEK Ladislav, IVANOV Pavel , ZUBATKINA Irina , SINYAVSKIY Oleg , RADATZ Matthias , MINDERMANN Thomas
発表年月日	2017/05/31
開催地 （都市, 国名）	Montreux, Switzerland
学会抄録	2017 ISRS2017 Program 19
概要	The objective of the present study was retrospective evaluation of results of Gamma Knife surgery (GKS) for uveal melanoma performed in 8 European Gamma Knife centers (Bucharest, Florence, Istanbul, Moscow, Prague, Saint Petersburg, Sheffield, and Zurich), which agreed to participate and provided required information. Study design presumed collection of the various data (62 investigated variables) on individual patients with creation of the integrated database for further statistical analysis. Primary end-points were overall survival, local tumor control, eye retention rate, and morbidity during follow-up. Secondary end-points were tumor response, preservation of visual function on the affected eye, and incidence of metastatic disease after GKS.In total 349 cases were collected. All patients were treated between July 2001 and October 2015. The stage of treated tumors corresponded to I, IIA, IIB, and IIIA in 26%, 43%, 23% and 7% of cases, respectively. Eye fixation was attained with retrobulbar anesthetic blocking in 65% of cases or suturing of rectus muscles in 24% of cases; in 11% of cases no eye fixation was done. Median marginal dose was 30 Gy (range, 25-30 Gy), median maximal dose was 50 Gy (range, 30-80 Gy), median maximal dose to the ipsilateral optic nerve was 8.7 Gy (range, 0.7