マスダ　シナコ   Shinako Masuda   増田　信奈子    所属   医学部 医学科    職種   助教
言語種別	日本語
発表タイトル	The role of fibroblasts in heart from the point of view of cardiac tissue engineering
会議名	第79回日本循環器学会学術集会
主催者	日本循環器学会
学会区分	全国規模の学会
招聘	招聘
発表形式	口頭
講演区分	シンポジウム・ワークショップ パネル（指名）
発表者・共同発表者	◎松浦勝久, 青木信奈子, 阪本覚, 萩原誠久, 清水達也
発表年月日	2015/04/25
開催地 （都市, 国名）	大阪市
概要	Herat tissue is composed of not only cardiomyocytes, but also vascular cells and fibroblasts. Although fibroblasts are existed in various types of tissue, the understating of the specific function and their underlying mechanisms of heart tissue-derived fibroblasts is fully insufficient, which might lead to miss out of chance to develop the new therapeutic strategies targeting fibroblasts in the pathological conditions. Accompanied with the heart tissue in vivo, the existence of fibroblasts is indispensable for the fabrication of functional bioengineered cardiac tissue. Recently we have found that fibroblasts isolated from heart tissues, but not dermal tissues, induce the proliferation of embryonic stem cell-derived cardiomyocytes, while fail to promote the endothelial cell microvascular network formation in 2D and 3D bioengineered cardiac tissue. These findings indicate that cardiac fibroblasts might have the properties to support the growth of heart tissue as interstitial cells in nature, while might not be ready to induce the angiogenesis in nature. In this session, I am going to show our recent findings on cardiac fibroblasts from the point of view of cardiac tissue engineering.