ムラガキ　ヨシヒロ   Muragaki Yoshihiro   村垣　善浩    所属   医学部 医学科（東京女子医科大学病院）    職種   客員教授
言語種別	日本語
発表タイトル	Proton MR spectroscopy in grading of intracranial gliomas 1P-P006-06
会議名	日本脳神経外科学会第73回学術総会
学会区分	全国規模の学会
発表形式	ポスター掲示
講演区分	一般
発表者・共同発表者	◎チエルノフミハイル, 村垣善浩
発表年月日	2014/10/09
開催地 （都市, 国名）	東京都
学会抄録	日本脳神経外科学会第73回学術総会
概要	Background. The objective of the present study was evaluation of the diagnostic efficacy of proton MRS for grading of intracranial gliomas.Methods. Original classification of the pathological MR spectra had been applied for evaluation of 38 low-grade and 33 high-grade intracranial gliomas. In each case long-echo single-voxel proton MRS was done.Results. Eight different types of the pathological MR spectra were noted in the present series, and 6 types had statistically significant association with tumor grade. Such metabolic patterns were identified in 45 cases (63%) and their identification had 0.78 and 0.83 cumulative positive predictive values for presence of low-grade and high-grade neoplasms, respectively. However, Type II A spectra with predominance of Cho and absence of Lac and Lip peaks (8 cases) and Type II B spectra with predominance of Cho, presenceof Lac peak, but absence of Lip peak (18 cases) did not permit reliable tumor grading. In such cases additional evaluation of NAA/Cho ratio with cutoff at 0.6 slightly improved diagnostic accuracy.Conclusion. In approximately 2/3 of cases pattern analysis of long-echo single-voxel proton MRS provides diagnostic information for reliable grading of intracranial gliomas.