ムラガキ　ヨシヒロ   Muragaki Yoshihiro   村垣　善浩    所属   医学部 医学科（東京女子医科大学病院）    職種   客員教授
言語種別	日本語
発表タイトル	Seizures in Patients with Newly Diagnosed IntracranialMeningiomas are Associated with Invasive Tumor Growth
会議名	日本脳神経外科学会　第72回学術総会
学会区分	国際学会及び海外の学会
発表形式	ポスター掲示
講演区分	一般
発表者・共同発表者	◎チエルノフミハイル, 糟谷英俊, 村垣善浩, 伊関洋, 堀智勝, 岡田芳和
発表年月日	2013/10/18
開催地 （都市, 国名）	横浜市
学会抄録	日本脳神経外科学会　第72回学術総会　プログラム 462
概要	3P-P129-08　ポスター：髄膜腫 3 INTRODUCTION. Symptomatic epilepsy is noted in approximately one third of patients with intracranial meningiomas. The objective of the present retrospective study was detailed characterization of the possible association between presence of seizures and macroscopically invasive tumor growth. METHODS. The analysis was limited to newly diagnosed convexity and parasagittal tumors (49 cases). There were 37 women and 12 men (mean age 57 years). The largest diameter of the neoplasm varied from 1 to 8 cm (mean 4 cm). In 9 patients (18%) the epileptic seizures were marked at least once during the history of the disease. All neoplasms underwent surgical removal. Invasive growth of the tumor to the pia mater or brain tissue was macroscopically identified intraoperatively in 25 cases. RESULTS. Presence of seizures during history of the disease was positively associated with the size of meningioma (P = 0.0271) and macroscopically invasive tumor growth (P = 0.0316). It demonstrated 0.32 sensitivity, 0.96 specificity, 0.89 positive predictive value, and 0.58 negative predictive value for invasive growth of the neoplasm. CONCLUSION. Presence of epileptic seizures in patients with convexity and parasagittal meningiomas may be predictive for invasive tumor growth.