ムラガキ　ヨシヒロ   MURAGAKI Yoshihiro   村垣　善浩    所属   医学部 医学科（東京女子医科大学病院）    職種   客員教授
Language	Japanese
Title	Proton MRS characteristics of intracranial meningiomas
Conference	第67回日本脳神経外科学会総会
Conference Type	Nationwide Conferences
Presentation Type	Poster notice
Lecture Type	General
Publisher and common publisher	◎Chernov, Mikhail , 糟谷英俊, 小野由子, 加藤宏一, 村垣善浩, 伊関洋, 堀智勝, 高倉公朋
Date	2008/10/02
Venue (city and name of the country)	岩手県
Society abstract	日本脳神経外科学会総会CD-ROM抄録集 67回,2J-10-P67-03 2008
Summary	2008-10-2:ポスター　髄膜腫・神経鞘腫1 OBJECTIVE The objective of the present analysis was evaluation of possible associations between content of choline-containing compounds (Cho) detected by proton magnetic resonance spectroscopy (MRS) with proliferative activity of meningiomas. MATERIALS AND METHODS One hundred patients (78 women and 22 men; mean age, 56 years) with histologically confirmed meningiomas were included in the study. Before surgery all tumors were evaluated with single-voxel long-echo MRS. RESULTS Histopathological investigation revealed 82 WHO grade I meningiomas, 11 – WHO grade II, and 7 – WHO grade III. MIB-1 index varied from 0% to 27.3% (mean, 3.2%), and in 18 cases, it was more, than 5%. Preoperative MRS-detected Cho content in meningiomas estimated relatively to normal brain tissue varied from 0.13 to 13.11 (mean, 2.28), and was significantly greater in cases with MIB-1 rate more, than 5% (3.13 vs. 2.09; P=0.0444). CONCLUSION MRS-detected Cho content seems to be associated with proliferative activity in meningiomas, and may be potentially helpful for non-invasive identification of biologically aggressive neoplasms.