ムラガキ ヨシヒロ   MURAGAKI Yoshihiro
  村垣 善浩
   所属   研究施設 研究施設
   職種   教授
言語種別 英語
種別 部分執筆
表題 Pathology and Genetics of Gliomas
書名 Progress in Neurological Surgery Vol.31 , Intracranial Gliomas Part II - Adjuvant Therapy
ISBNコード 9783318060584
編者名 CHERNOV,Mikhail F.,MURAGAKI ,Yoshihiro,Kesari S.,McCutcheon I.E.
総ページ数 252
出版社 Karger AG
出版地
(都市, 国名)
Basel,Switzerland
著者・共著者 KOMORI Takashi, MURAGAKI Yoshihiro, CHERNOV Mikhail
発行年月 2018/01
概要 Current World Health Organization (WHO) classification of the neuroepithelial tumors is cell lineage-oriented and based on a presumed developmental tree of the central nervous system (CNS). It defines three main groups of gliomas, namely astrocytomas, oligodendrogliomas, and ependymomas, and additionally presumes their 4-tiered histopathological grading (WHO grades I to IV). Nevertheless, the impact of tumor pathology on clinically related parameters may be frequently much better predicted by genetics, than by histological appearance of the lesion. Recent studies have revealed several major molecular alterations typical for different types of neoplasms, such as IDH1/IDH2 mutations in diffusely infiltrating gliomas, mutations of TP53 and ATRX in astrocytomas, 1p/19q co-deletion in oligodendrogliomas, mutations of TERT promoter in oligodendrogliomas and IDH wild-type glioblastomas, and mutations or fusions of BRAF in circumscribed astrocytomas, particularly in children. Identification of those and several other genetic abnormalities in the tumor is clinically important and may help clinicians to determine proper treatment strategy and to predict prognosis. Therefore, the updated WHO classification of CNS tumors (2016) considers not only phenotype, but also some genetic characteristics of gliomas.
researchmap用URL https://doi.org/10.1159/000466835