カワマタ　タカカズ   KAWAMATA Takakazu   川俣　貴一    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
言語種別	英語
種別	部分執筆
表題	RNF213 and Clinical Feature
書名	Moyamoya disease: Current Knowledge and Future Perspectives
ISBNコード	978-9813364035
編者名	Satoshi Kuroda
版・巻・頁	pp.61-72
出版社	Springer
出版地 （都市, 国名）	Singapore
著者・共著者	野村 俊介, 赤川 浩之, 山口 浩司, 川島 明次, 川俣 貴一
発行年月	2021/02/27
概要	This book brings together the latest knowledge on moyamoya disease, covering diagnostic criteria, status as a disease entity, genetic aspects, pathophysiology, novel neuroradiological findings, and surgical therapy. Information is also provided on recent basic and clinical research with the aim of identifying future perspectives on the disease. Since moyamoya disease was first reported in an English language article more than 50 years ago, our understanding of it has advanced considerably. Genetic and radiological analysis has delivered novel insights, and the latest multicenter studies are changing routine diagnosis and surgical therapy. The gene encoding the ring finger protein 213 (RNF213) has been identified as a susceptibility gene for moyamoya disease. Indications and procedures for surgical revascularization have been revised, with resultant improvements in outcomes, and studies performed over the past decade have provided new knowledge on the neuroradiological findings before and after surgery. In describing these advances, this book will be an invaluable asset for all general physicians, pediatricians, neurologists, radiologists, and neurosurgeons who care for patients with moyamoya disease across the world