YAMATO Masayuki
Department Research Institutes and Facilities, Research Institutes and Facilities Position Professor |
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Language | English |
Category | Chapter contribution |
Title | 5.35 - Biomaterials: Temperature-Responsive Polymer |
Book title | Comprehensive Biotechnology |
ISBN | 978-0-444-64047-5 |
Editor | Murray Moo-Young |
Edition, Volume, Page | 3rd,5,pp.457-470 |
Total page number | 4870 |
Publisher | Elsevier |
Publication place (City and country) | Oxford, UK |
Author and coauthor | KOBAYASHI Jun, AKIYAMA Yoshikatsu, YAMATO Masayuki, OKANO Teruo |
Publication date | 2019/07 |
Summary | Temperature-responsive polymers are used as switching sequences to regulate interfacial phenomena and initiate unique biomedical and biotechnological applications. Special attention has been paid to poly(N-isopropylacrylamide) (PIPAAm), which exhibits a reversible temperature-dependent phase transition in aqueous solutions at the lower critical solution temperature (LCST) of 32 °C. Soluble and cross-linked PIPAAm undergo temperature-responsive dynamic volume changes, which are utilized for regulating on–off drug release and mimicking biological functions. However, no clinical studies on implantation of PIPAAm-based biomaterials have been reported. By contrast, PIPAAm-modified intelligent surfaces, which exhibit hydrophilic/hydrophobic alteration in response to temperature change, are readily adaptive to clinical applications because no PIPAAm molecules are eluted in the solution during the interaction with biological materials. The PIPAAm-immobilized surfaces achieve purifying bioactive molecules in aqueous media and recovering cell sheets to create three dimensional tissues for regeneration of damaged tissues only by changing temperature. |